Role of the 3' Long Open Reading Frame Region of Bovine Leukemia Virus in the Maintenance of Cell Transformation

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1985 Jun 1

PMID 2987544

Citations 22

Authors

R Kettmann

Y Cleuter

D Gregoire

A Burny

Affiliations

Soon will be listed here.

Abstract

Viral RNA expression was studied by dot blot hybridization with polyadenylated RNAs extracted from a bovine (YR-1) and an ovine (YR-2) tumor cell clone. Both clones were derived from in vivo bovine leukemia virus-induced tumors. The probes used were either the bovine leukemia virus information or only the long open reading frame sequences. No viral RNA corresponding to the bovine leukemia virus long open reading frame region was detected in YR-2, and a very limited amount of bovine leukemia virus messages was unraveled in YR-1. These results strongly suggest that viral expression, even in the long open reading frame region, is not required to maintain transformation of at least some tumor cells.

Citing Articles

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Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome.

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