Phytohemagglutinin Activation of the Transcription of the Bovine Leukemia Virus Genome Requires De Novo Protein Synthesis

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1985 Jun 1

PMID 2987537

Citations 4

Authors

R Chatterjee

P Gupta

S V Kashmiri

J F Ferrer

Affiliations

Soon will be listed here.

Abstract

Addition of supramitogenic doses of phytohemagglutinin (PHA) to short-term cultures of neoplastic or nonneoplastic lymphocytes infected with bovine leukemia virus increased the synthesis of the major core virion antigen (p25) by 5- to 10-fold. Such stimulation was not due to the mitogenic effect of PHA or to a generalized increase in cellular RNA or protein synthesis but rather to enhanced transcription of the viral genome by a PHA-induced protein.

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