Inflammatory Dietary Pattern, Genetic Variant, and the Risk of Colorectal Cancer

Overview

Journal Nutrients

Date 2018 Jun 8

PMID 29874787

Citations 11

Authors

Young Ae Cho

Jeonghee Lee

Jae Hwan Oh

Hee Jin Chang

Dae Kyung Sohn

Aesun Shin

Jeongseon Kim

Affiliations

Soon will be listed here.

Abstract

A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals' genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65⁻4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81⁻14.62) for the highest quartile vs. lowest quartile). When stratified by the rs763780 genotype, this association was stronger for individuals carrying the C allele ( for interaction = 0.034), particularly for individuals with rectal cancer ( for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the rs763780 genotype and anatomic site.

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