Rab1a Rescues the Toxicity of PRAF3

Overview

Journal Biochem Biophys Rep

Specialty Biochemistry

Date 2018 Jun 7

PMID 29872729

Authors

Hiroyuki Oshikane

Masahiko Watabe

Kazue Kikuchi-Utsumi

Toshio Nakaki

Affiliations

Soon will be listed here.

Abstract

The PRA1-superfamily member PRAF3 plays pivotal roles in membrane traffic as a GDI displacement factor via physical interaction with a variety of Rab proteins, as well as in the modulation of antioxidant glutathione through its interaction with EAAC1 (SLC1A1). Overproduction of PRAF3 is known to be toxic to the host cells, although the factors capable of cancelling the toxicity remained unknown. We here show that Rab1a can rescue the cytotoxicity caused by PRAF3 possibly by "positively" regulating ER-Golgi trafficking, cancelling the "negative" modulation by PRAF3. Our results illuminate the close physiological relationship between PRAF3 and Rab proteins.

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