Differentially Expressed Circulating MicroRNAs in the Development of Acute Diabetic Charcot Foot

Overview

Journal Epigenomics

Specialty Genetics

Date 2018 Jun 6

PMID 29869523

Citations 5

Authors

Jennifer Pasquier

Vimal Ramachandran

Mohd Rasheed Abu-Qaoud

Binitha Thomas

Manasi J Benurwar

Omar Chidiac

Jessica Hoarau-Vechot

Amal Robay

Khalid Fakhro

Robert A Menzies

Amin Jayyousi

Mahmoud Zirie

Jassim Al Suwaidi

Rayaz A Malik

Talal K Talal

Seyed Hani Najafi-Shoushtari

Arash Rafii

Charbel Abi Khalil

Affiliations

Soon will be listed here.

Abstract

Aim: Charcot foot (CF) is a rare complication of Type 2 diabetes (T2D).

Materials & Methods: We assessed circulating miRNAs in 17 patients with T2D and acute CF (G1), 17 patients with T2D (G2) and equivalent neuropathy and 17 patients with T2D without neuropathy (G3) using the high-throughput miRNA expression profiling.

Results: 51 significantly deregulated miRNAs were identified in G1 versus G2, 37 in G1 versus G3 and 64 in G2 versus G3. Furthermore, we demonstrated that 16 miRNAs differentially expressed between G1 versus G2 could be involved in osteoclastic differentiation. Among them, eight are key factors involved in CF pathophysiology.

Conclusion: Our data reveal that CF patients exhibit an altered expression profile of circulating miRNAs.

Citing Articles

Altered Circulating microRNAs in Patients with Diabetic Neuropathy and Corneal Nerve Loss: A Pilot Study.

Khan A, Pasquier J, Ramachandran V, Ponirakis G, Petropoulos I, Chidiac O J Clin Med. 2022; 11(6).

PMID: 35329958 PMC: 8956033. DOI: 10.3390/jcm11061632.

The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds.

Li J, Wei M, Liu X, Xiao S, Cai Y, Li F Mol Ther Nucleic Acids. 2021; 24:554-578.

PMID: 33981479 PMC: 8063712. DOI: 10.1016/j.omtn.2021.03.015.

Vitamin C supplementation reduces expression of circulating miR-451a in subjects with poorly controlled type 2 diabetes mellitus and high oxidative stress.

Ruknarong L, Boonthongkaew C, Chuangchot N, Jumnainsong A, Leelayuwat N, Jusakul A PeerJ. 2021; 9:e10776.

PMID: 33604180 PMC: 7868066. DOI: 10.7717/peerj.10776.

Mechanistic Actions of microRNAs in Diabetic Wound Healing.

Petkovic M, Sorensen A, Leal E, Carvalho E, Dalgaard L Cells. 2020; 9(10).

PMID: 33023156 PMC: 7601058. DOI: 10.3390/cells9102228.

Non-coding RNAs in neuropathic pain.

Kalpachidou T, Kummer K, Kress M Neuronal Signal. 2020; 4(1):NS20190099.

PMID: 32587755 PMC: 7306520. DOI: 10.1042/NS20190099.

References

Mabilleau G, Petrova N, Edmonds M, Sabokbar A . Increased osteoclastic activity in acute Charcot's osteoarthropathy: the role of receptor activator of nuclear factor-kappaB ligand. Diabetologia. 2008; 51(6):1035-40. PMC: 2362134. DOI: 10.1007/s00125-008-0992-1. View

Zou M, Wang F, Gao R, Wu J, Ou Y, Chen X . Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts. Sci Rep. 2016; 6:24747. PMC: 4838850. DOI: 10.1038/srep24747. View

Sun Y, Peng R, Peng H, Liu H, Wen L, Wu T . miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy. Mol Cell Endocrinol. 2016; 433:75-86. DOI: 10.1016/j.mce.2016.06.004. View

Pop-Busui R, Boulton A, Feldman E, Bril V, Freeman R, Malik R . Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2016; 40(1):136-154. PMC: 6977405. DOI: 10.2337/dc16-2042. View

Tang Y, Zhang Y, Chen Y, Xiang Y, Shen C, Li Y . The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease. Sci Rep. 2015; 5:15132. PMC: 4602285. DOI: 10.1038/srep15132. View

Khan F, Pandian V, Ramraj S, Aravindan S, Herman T, Aravindan N . Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. BMC Genomics. 2015; 16:501. PMC: 4491873. DOI: 10.1186/s12864-015-1642-x. View

Song J, Kang Y, Yoon S, Chun C, Jin E . HIF-1α:CRAT:miR-144-3p axis dysregulation promotes osteoarthritis chondrocyte apoptosis and VLCFA accumulation. Oncotarget. 2017; 8(41):69351-69361. PMC: 5642483. DOI: 10.18632/oncotarget.20615. View

Wang Y, Zhang Y, Yang T, Zhao W, Wang N, Li P . Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells. Oncotarget. 2017; 8(35):59417-59434. PMC: 5601743. DOI: 10.18632/oncotarget.19727. View

Petrova N, Edmonds M . Acute Charcot neuro-osteoarthropathy. Diabetes Metab Res Rev. 2015; 32 Suppl 1:281-6. DOI: 10.1002/dmrr.2734. View

10.

Arroyo J, Chevillet J, Kroh E, Ruf I, Pritchard C, Gibson D . Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A. 2011; 108(12):5003-8. PMC: 3064324. DOI: 10.1073/pnas.1019055108. View

11.

Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K . Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008; 18(10):997-1006. DOI: 10.1038/cr.2008.282. View

12.

Uccioli L, Sinistro A, Almerighi C, Ciaprini C, Cavazza A, Giurato L . Proinflammatory modulation of the surface and cytokine phenotype of monocytes in patients with acute Charcot foot. Diabetes Care. 2009; 33(2):350-5. PMC: 2809281. DOI: 10.2337/dc09-1141. View

13.

Mestdagh P, Hartmann N, Baeriswyl L, Andreasen D, Bernard N, Chen C . Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods. 2014; 11(8):809-15. DOI: 10.1038/nmeth.3014. View

14.

Kim B, Jung J, Jeon J, Kim H, Suh C . Circulating hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p may be novel biomarkers in systemic lupus erythematosus. HLA. 2016; 88(4):187-93. DOI: 10.1111/tan.12874. View

15.

Tuttolomondo A, Maida C, Pinto A . Diabetic foot syndrome as a possible cardiovascular marker in diabetic patients. J Diabetes Res. 2015; 2015:268390. PMC: 4391526. DOI: 10.1155/2015/268390. View

16.

Saeedi Borujeni M, Esfandiary E, Taheripak G, Codoner-Franch P, Alonso-Iglesias E, Mirzaei H . Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome. J Cell Biochem. 2017; 119(2):1257-1272. DOI: 10.1002/jcb.26271. View

17.

Shen H, Li W, Tian Y, Xu P, Wang H, Zhang J . Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma. J Cell Biochem. 2015; 116(8):1563-73. DOI: 10.1002/jcb.25110. View

18.

Bayraktar R, Van Roosbroeck K, Calin G . Cell-to-cell communication: microRNAs as hormones. Mol Oncol. 2017; 11(12):1673-1686. PMC: 5709614. DOI: 10.1002/1878-0261.12144. View

19.

Wang K, Yuan Y, Cho J, McClarty S, Baxter D, Galas D . Comparing the MicroRNA spectrum between serum and plasma. PLoS One. 2012; 7(7):e41561. PMC: 3409228. DOI: 10.1371/journal.pone.0041561. View

20.

Li Q, Chen L, Chen D, Wu X, Chen M . Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease. Am J Transl Res. 2015; 7(2):393-400. PMC: 4399102. View