Characterization of a NIR Absorbing Thienyl Curcumin Contrast Agent for Photoacoustic Imaging

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Jun 6

PMID 29868656

Citations 2

Authors

Stephanie Bellinger

Maryam Hatamimoslehabadi

Raymond E Borg

Jeffrey La

Peter Catsoulis

Farha Mithila

Chandra Yelleswarapu

Jonathan Rochford

Affiliations

Soon will be listed here.

Abstract

The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range.

Citing Articles

Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds.

Merkes J, Zhu L, Bahukhandi S, Rueping M, Kiessling F, Banala S Int J Mol Sci. 2020; 21(9).

PMID: 32349297 PMC: 7247687. DOI: 10.3390/ijms21093082.

Photophysical and Photoacoustic Properties of π-Extended Curcumin Dyes. Effects of the Terminal Dimethylamino Electron-donor and the Bridging Aryl Ring.

Borg R, Hatamimoslehabadi M, Bellinger S, La J, Mithila F, Yelleswarapu C Photochem Photobiol. 2018; 95(1):280-292.

PMID: 29989174 PMC: 6328350. DOI: 10.1111/php.12980.

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