Is There a Role of Pharmacogenomics in Africa

Overview

Journal Glob Health Epidemiol Genom

Specialties General Medicine
Public Health

Date 2018 Jun 6

PMID 29868201

Citations 7

Authors

A Matimba

M Dhoro

C Dandara

Affiliations

Soon will be listed here.

Abstract

Pharmacogenomics has the potential of transforming clinical research and improving healthcare in sub-Saharan Africa (SSA). The role of African genome diversity and the opportunities for pharmacogenomics research are highlighted and will enable discovery of novel genetic mechanisms and validation of established markers. African genomics and biobank consortia will play an important role in building capacity for pharmacogenomics in SSA.

Citing Articles

Genetic Diversity Landscape in African Population: A Review of Implications for Personalized and Precision Medicine.

Sibomana O Pharmgenomics Pers Med. 2024; 17:487-496.

PMID: 39555236 PMC: 11566596. DOI: 10.2147/PGPM.S485452.

The Role of Pharmacogenomics Studies for Precision Medicine Among Ethiopian Patients and Their Clinical Implications: A Scoping Review.

Getahun K, Angaw D, Asres M, Kahaliw W, Petros Z, Abay S Pharmgenomics Pers Med. 2024; 17:347-361.

PMID: 38974617 PMC: 11226858. DOI: 10.2147/PGPM.S454328.

Cardiovascular precision medicine - A pharmacogenomic perspective.

Padmanabhan S, Du Toit C, Dominiczak A Camb Prism Precis Med. 2024; 1:e28.

PMID: 38550953 PMC: 10953758. DOI: 10.1017/pcm.2023.17.

Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment.

Zdesenko G, Mduluza T, Mutapi F Front Genet. 2022; 13:914372.

PMID: 35754834 PMC: 9213834. DOI: 10.3389/fgene.2022.914372.

Health equality, race and pharmacogenomics.

Magavern E, Gurdasani D, Ng F, Lee S Br J Clin Pharmacol. 2021; 88(1):27-33.

PMID: 34251046 PMC: 8752640. DOI: 10.1111/bcp.14983.

References

Limaye N . Pharmacogenomics, Theranostics and Personalized Medicine - the complexities of clinical trials: challenges in the developing world. Appl Transl Genom. 2016; 2:17-21. PMC: 5133334. DOI: 10.1016/j.atg.2013.05.002. View

Thorn C, Klein T, Altman R . Pharmacogenomics and bioinformatics: PharmGKB. Pharmacogenomics. 2010; 11(4):501-5. PMC: 3098752. DOI: 10.2217/pgs.10.15. View

Rotimi C, Abayomi A, Abimiku A, May Adabayeri V, Adebamowo C, Adebiyi E . Research capacity. Enabling the genomic revolution in Africa. Science. 2014; 344(6190):1346-8. PMC: 4138491. DOI: 10.1126/science.1251546. View

Gurdasani D, Carstensen T, Tekola-Ayele F, Pagani L, Tachmazidou I, Hatzikotoulas K . The African Genome Variation Project shapes medical genetics in Africa. Nature. 2014; 517(7534):327-32. PMC: 4297536. DOI: 10.1038/nature13997. View

Thomford N, Dzobo K, Chopera D, Wonkam A, Skelton M, Blackhurst D . Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition. Pharmaceuticals (Basel). 2015; 8(3):637-63. PMC: 4588186. DOI: 10.3390/ph8030637. View

Mukonzo J, Owen J, Ogwal-Okeng J, Kuteesa R, Nanzigu S, Sewankambo N . Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes. PLoS One. 2014; 9(1):e86919. PMC: 3909010. DOI: 10.1371/journal.pone.0086919. View

Ramsay M, Sankoh O . African partnerships through the H3Africa Consortium bring a genomic dimension to longitudinal population studies on the continent. Int J Epidemiol. 2015; 45(2):305-8. PMC: 5841636. DOI: 10.1093/ije/dyv187. View

Dandara C, Lombard Z, Du Plooy I, McLellan T, Norris S, Ramsay M . Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity. Pharmacogenomics. 2011; 12(12):1663-70. DOI: 10.2217/pgs.11.106. View

Maranville J, Cox N . Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits. Pharmacogenomics J. 2015; 16(4):388-92. PMC: 4704992. DOI: 10.1038/tpj.2015.47. View

10.

Monera T, Wolfe A, Maponga C, Benet L, Guglielmo J . Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2009; 2(5):379-83. PMC: 5385924. DOI: 10.3855/jidc.201. View

11.

Pal A, Bawankule D, Darokar M, Gupta S, Arya J, Shanker K . Influence of Moringa oleifera on pharmacokinetic disposition of rifampicin using HPLC-PDA method: a pre-clinical study. Biomed Chromatogr. 2010; 25(6):641-5. DOI: 10.1002/bmc.1494. View

12.

Dhoro M, Zvada S, Ngara B, Nhachi C, Kadzirange G, Chonzi P . CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe. BMC Pharmacol Toxicol. 2015; 16:4. PMC: 4405819. DOI: 10.1186/s40360-015-0004-2. View

13.

McDonagh E, Whirl-Carrillo M, Garten Y, Altman R, Klein T . From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. Biomark Med. 2011; 5(6):795-806. PMC: 3339046. DOI: 10.2217/bmm.11.94. View

14.

Burmester J, Sedova M, Shapero M, Mansfield E . DMET microarray technology for pharmacogenomics-based personalized medicine. Methods Mol Biol. 2010; 632:99-124. DOI: 10.1007/978-1-60761-663-4_7. View

15.

Kuete V, Efferth T . Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy. J Ethnopharmacol. 2011; 137(1):752-66. DOI: 10.1016/j.jep.2011.06.035. View

16.

Tekola-Ayele F, Adeyemo A, Aseffa A, Hailu E, Finan C, Davey G . Clinical and pharmacogenomic implications of genetic variation in a Southern Ethiopian population. Pharmacogenomics J. 2014; 15(1):101-108. PMC: 4277706. DOI: 10.1038/tpj.2014.39. View

17.

Sirugo G, Hennig B, Adeyemo A, Matimba A, Newport M, Ibrahim M . Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics. Hum Genet. 2008; 123(6):557-98. DOI: 10.1007/s00439-008-0511-y. View