Greater Colo-Rectal Activation Phenotype in Exercised Mdx Mice

Overview

Journal PLoS Curr

Specialty General Medicine

Date 2018 Jun 5

PMID 29862132

Citations 1

Authors

Marie Nearing

James Novak

Terence Partridge

Affiliations

Soon will be listed here.

Abstract

Introduction: Duchenne Muscular Dystrophy is a genetic disease that is caused by a deficiency of dystrophin protein. Both Duchenne Muscular Dystrophy patients and dystrophic mice suffer from intestinal dysfunction.

Methods: The present study arose from a chance observation of differences in fecal output of dystrophic vs. normal mice during 20-minutes of forced continuous treadmill exercise. Here, we report on the effects of exercise on fecal output in two different dystrophic mutants and their normal background control strains. All fecal materials evacuated during exercise were counted, dried and weighed.

Results: Mice of both mutant dystrophic strains produced significantly more fecal material during the exercise bout than the relevant control strains.

Iscussion: We propose that exercise--induced Colo--Rectal Activation Phenotype test could be used as a simple, highly sensitive, non-invasive biomarker to determine efficacy of dystrophin replacement therapies.

Citing Articles

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation.

Swiderski K, Bindon R, Trieu J, Naim T, Schokman S, Swaminathan M J Neurogastroenterol Motil. 2019; 26(1):133-146.

PMID: 31715094 PMC: 6955187. DOI: 10.5056/jnm19029.

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