Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut

Overview

Journal AIDS Res Hum Retroviruses

Publisher Mary Ann Liebert

Specialty Infectious Diseases

Date 2018 Jun 5

PMID 29860868

Citations 4

Authors

Sallie Permar

Ofer Levy

Tobias R Kollman

Anjali Singh

Kristina De Paris

Affiliations

Soon will be listed here.

Abstract

Limited success of current HIV-1 vaccines warrants new approaches. We discuss feasibility and potential benefits of early life HIV-1 immunization followed by vaccine boosts during childhood that may enable maturation of vaccine-induced broad anti-HIV-1 immunity over several years. By initiating this immunization approach in the very young, well before sexual debut, such a strategy may dramatically reduce the risk of HIV-1 infection.

Citing Articles

Safety and implementation of a phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns.

Violari A, Otwombe K, Hahn W, Chen S, Josipovic D, Baba V medRxiv. 2024; .

PMID: 39484284 PMC: 11527060. DOI: 10.1101/2024.10.15.24315548.

Bringing the path toward an HIV-1 vaccine into focus.

Lopez Angel C, Tomaras G PLoS Pathog. 2020; 16(9):e1008663.

PMID: 32913360 PMC: 7482965. DOI: 10.1371/journal.ppat.1008663.

Immunization: vital progress, unfinished agenda.

Piot P, Larson H, OBrien K, Nkengasong J, Ng E, Sow S Nature. 2019; 575(7781):119-129.

PMID: 31695203 DOI: 10.1038/s41586-019-1656-7.

AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition.

Singh A, Permar S, Kollmann T, Levy O, Marovich M, De Paris K mSphere. 2019; 4(4).

PMID: 31315966 PMC: 6637046. DOI: 10.1128/mSphere.00320-19.

References

Fouda G, Cunningham C, McFarland E, Borkowsky W, Muresan P, Pollara J . Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. J Infect Dis. 2014; 211(4):508-17. PMC: 4318918. DOI: 10.1093/infdis/jiu444. View

Chung A, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S . Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines. Sci Transl Med. 2014; 6(228):228ra38. DOI: 10.1126/scitranslmed.3007736. View

Van Rompay K, Abel K, Lawson J, Singh R, Schmidt K, Evans T . Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV. J Acquir Immune Defic Syndr. 2005; 38(2):124-34. DOI: 10.1097/00126334-200502010-00002. View

Kollmann T, Kampmann B, Mazmanian S, Marchant A, Levy O . Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. Immunity. 2017; 46(3):350-363. DOI: 10.1016/j.immuni.2017.03.009. View

Giladi A, Amit I . Immunology, one cell at a time. Nature. 2017; 547(7661):27-29. DOI: 10.1038/547027a. View

Simonich C, Williams K, Verkerke H, Williams J, Nduati R, Lee K . HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant. Cell. 2016; 166(1):77-87. PMC: 4930401. DOI: 10.1016/j.cell.2016.05.055. View

Van Rompay K, Berardi C, Tarara R, Canfield D, Valverde C, Montefiori D . Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection. J Infect Dis. 1998; 177(5):1247-59. DOI: 10.1086/515270. View

Ackerman M, Barouch D, Alter G . Systems serology for evaluation of HIV vaccine trials. Immunol Rev. 2017; 275(1):262-270. PMC: 5292205. DOI: 10.1111/imr.12503. View

Pettengill M, Levy O . Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage. Front Immunol. 2016; 7:121. PMC: 4812068. DOI: 10.3389/fimmu.2016.00121. View

10.

Levy O, Zarember K, Roy R, Cywes C, Godowski P, Wessels M . Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol. 2004; 173(7):4627-34. DOI: 10.4049/jimmunol.173.7.4627. View

11.

Siegrist C . Neonatal and early life vaccinology. Vaccine. 2001; 19(25-26):3331-46. DOI: 10.1016/s0264-410x(01)00028-7. View

12.

Hessell A, Haigwood N . Animal models in HIV-1 protection and therapy. Curr Opin HIV AIDS. 2015; 10(3):170-6. PMC: 4526147. DOI: 10.1097/COH.0000000000000152. View

13.

Tourneur E, Chassin C . Neonatal immune adaptation of the gut and its role during infections. Clin Dev Immunol. 2013; 2013:270301. PMC: 3659470. DOI: 10.1155/2013/270301. View

14.

Hessell A, Jaworski J, Epson E, Matsuda K, Pandey S, Kahl C . Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques. Nat Med. 2016; 22(4):362-8. PMC: 4983100. DOI: 10.1038/nm.4063. View

15.

Dowling D, van Haren S, Scheid A, Bergelson I, Kim D, Mancuso C . TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. JCI Insight. 2017; 2(6):e91020. PMC: 5360187. DOI: 10.1172/jci.insight.91020. View

16.

Abdool Karim Q, Baxter C, Birx D . Prevention of HIV in Adolescent Girls and Young Women: Key to an AIDS-Free Generation. J Acquir Immune Defic Syndr. 2017; 75 Suppl 1:S17-S26. DOI: 10.1097/QAI.0000000000001316. View

17.

Oh D, Dowling D, Ahmed S, Choi H, Brightman S, Bergelson I . Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics. 2016; 15(6):1877-94. PMC: 5083103. DOI: 10.1074/mcp.M115.055541. View

18.

Brown E, Dowell K, Boesch A, Normandin E, Mahan A, Chu T . Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles. J Immunol Methods. 2017; 443:33-44. PMC: 5333794. DOI: 10.1016/j.jim.2017.01.010. View

19.

Irewole-Ojo F, Senbanjo I, Oduwole A, Njokanma O . Age of pubertal events among school girls in Lagos, Nigeria. J Pediatr Endocrinol Metab. 2018; 31(3):313-321. DOI: 10.1515/jpem-2017-0344. View

20.

Van Rompay K, Cherrington J, Marthas M, Berardi C, Mulato A, Spinner A . 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob Agents Chemother. 1996; 40(11):2586-91. PMC: 163581. DOI: 10.1128/AAC.40.11.2586. View