Heritable Formation of Pancreatic Beta-cell Tumours in Transgenic Mice Expressing Recombinant Insulin/simian Virus 40 Oncogenes

Overview

Journal Nature

Specialty Science

Date 1985 May 9

PMID 2986015

Citations 432

Authors

D Hanahan

Affiliations

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Abstract

Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.

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