Extension of C. Elegans Lifespan Using the ·NO-delivery Dinitrosyl Iron Complexes

Overview

Journal J Biol Inorg Chem

Publisher Springer

Specialty Biochemistry

Date 2018 Jun 3

PMID 29858679

Citations 4

Authors

Hsiao-Wen Huang

Yen-Hung Lin

Min-Hsuan Lin

Ya-Rong Huang

Chih-Hung Chou

Hsiao-Chin Hong

Mei-Ren Wang

Yu-Ting Tseng

Po-Chun Liao

Min-Chuan Chung

Yu-Jie Ma

Shou-Cheng Wu

Yung-Jen Chuang

Horng-Dar Wang

Yun-Ming Wang

Hsien-Da Huang

Tsai-Te Lu

Wen-Feng Liaw

Affiliations

Soon will be listed here.

Abstract

The ubiquitous and emerging physiology function of endogenous nitric oxide in vascular, myocardial, immune, and neuronal systems prompts chemists to develop a prodrug for the controlled delivery of ·NO in vivo and for the translational biomedical application. Inspired by the discovery of natural [Fe(NO)] motif, herein, we develop the synthetic dinitrosyl iron complexes (DNICs) [Fe(μ-SR)(NO)] (1) as a universal platform for the O-triggered release of ·NO, for the regulation of ·NO-release kinetics (half-life = 0.6-27.4 h), and for the activation of physiological function of ·NO. Using C. elegans as a model organism, the ·NO-delivery DNIC 1 regulates IIS signaling pathway, AMPK signaling pathway, and mitochondrial function pathway to extend the lifespan and to delay the aging process based on the lifespan analysis, SA-βgal activity assay, and next-generation RNA sequencing analysis. This study unveils the anti-aging effect of ·NO and develops DNICs as a chemical biology probe for the continued discovery of unprecedented NO physiology.

Citing Articles

Mechanistic and Kinetic Insights into Cellular Uptake of Biomimetic Dinitrosyl Iron Complexes and Intracellular Delivery of NO for Activation of Cytoprotective HO-1.

Chiu H, Chau Fang A, Chen Y, Koi R, Yu K, Hsieh L JACS Au. 2024; 4(4):1550-1569.

PMID: 38665642 PMC: 11040670. DOI: 10.1021/jacsau.4c00064.

Cell-Penetrating Delivery of Nitric Oxide by Biocompatible Dinitrosyl Iron Complex and Its Dermato-Physiological Implications.

Chen Y, Chen Y, Chiu H, Ko Y, Wang R, Wang W Int J Mol Sci. 2021; 22(18).

PMID: 34576264 PMC: 8469893. DOI: 10.3390/ijms221810101.

Assessing the cognitive status of Drosophila by the value-based feeding decision.

Yu C, Chang F, Hong Y, Li J, Chen P, Chen C NPJ Aging Mech Dis. 2021; 7(1):24.

PMID: 34526491 PMC: 8443761. DOI: 10.1038/s41514-021-00075-6.

Endogenous Conjugation of Biomimetic Dinitrosyl Iron Complex with Protein Vehicles for Oral Delivery of Nitric Oxide to Brain and Activation of Hippocampal Neurogenesis.

Wu C, Huang Y, Hong Y, Liu Y, Narwane M, Chang Y JACS Au. 2021; 1(7):998-1013.

PMID: 34467346 PMC: 8395708. DOI: 10.1021/jacsau.1c00160.

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