Metabotypes of Response to Bariatric Surgery Independent of the Magnitude of Weight Loss

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Jun 2

PMID 29856816

Citations 7

Authors

Magali Palau-Rodriguez

Sara Tulipani

Anna Marco-Ramell

Antonio Minarro

Olga Jauregui

Alex Sanchez-Pla

Bruno Ramos-Molina

Francisco J Tinahones

Cristina Andres-Lacueva

Affiliations

Soon will be listed here.

Abstract

Objective: Bariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations.

Methods: We used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery.

Results: For the first time, global metabolic changes following bariatric surgery independent of the baseline health status of the subjects have been revealed. We identify two metabolic phenotypes (metabotypes) at the interval 6 months-baseline after surgery, which presented differences in the levels of compounds of urea metabolism, gluconeogenic precursors and (lyso)phospholipid particles. Clinically, metabotypes were different in terms of the degree of improvement in insulin resistance, cholesterol, low-density lipoproteins and uric acid independent of the magnitude of weight loss.

Conclusions: This study opens new perspectives and new hypotheses on the metabolic benefits of bariatric surgery and understanding of the biology of obesity and its associated diseases.

Citing Articles

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Inflammation and Metabolism of Influenza-Stimulated Peripheral Blood Mononuclear Cells From Adults With Obesity Following Bariatric Surgery.

Green W, Alwarawrah Y, Al-Shaer A, Shi Q, Armstrong M, Manke J J Infect Dis. 2022; 227(1):92-102.

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Regulation of body weight: Lessons learned from bariatric surgery.

Albaugh V, He Y, Munzberg H, Morrison C, Yu S, Berthoud H Mol Metab. 2022; 68():101517.

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Metabolomic signatures after bariatric surgery - a systematic review.

Vaz M, Pereira S, Monteiro M Rev Endocr Metab Disord. 2021; 23(3):503-519.

PMID: 34855133 PMC: 9156502. DOI: 10.1007/s11154-021-09695-5.

Long-Term Effects of Bariatric Surgery on Gut Microbiota Composition and Faecal Metabolome Related to Obesity Remission.

Juarez-Fernandez M, Roman-Saguillo S, Porras D, Garcia-Mediavilla M, Linares P, Ballesteros-Pomar M Nutrients. 2021; 13(8).

PMID: 34444679 PMC: 8397959. DOI: 10.3390/nu13082519.

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