Effect of Yin-Xing-Tong-Zhi Tablets on Improving Vascular Cognitive Impairment No Dementia

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Jun 2

PMID 29853963

Citations 1

Authors

Weidong Pan

Wei Zhu

Qi Gao

Weilong Liao

Penglin Gao

Te Liu

Affiliations

Soon will be listed here.

Abstract

Objective: Observe the effect of the Chinese herbal extracts, Yin-Xing-Tong-Zhi, in tablet form, on improving vascular cognitive impairment no dementia (VCIND).

Methods: Sixty-eight patients with VCIND were divided randomly into treatment and placebo groups with oral administration of Yin-Xing-Tong-Zhi tablets (YXTZTs) or placebo, respectively, for 24 weeks. Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale score, MMSE score, Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) score, expression of interleukin- (IL-) 6, IL-8, and tumor necrosis factor- (TNF-) in serum, and variation of blood-lipid levels were evaluated at different time points.

Results: At weeks 12 and 24, the scores for the ADAS-Cog, CIBIC-Plus, and MMSE of the treatment group were significantly lower than those of the control group ( < 0.05). All clinical scales at week 24 of the control group were significantly different from those before treatment ( < 0.05). Expression of IL-6, IL-8, and TNF- in the two groups was reduced significantly with variation of the clinical scales of cognitive impairment.

Conclusion: YXTZTs may delay the development of cognitive impairment in VCIND patients by modulating expression of VCIND-associated proinflammatory factors.

Citing Articles

Post-stroke cognitive impairment and synaptic plasticity: A review about the mechanisms and Chinese herbal drugs strategies.

Chi X, Wang L, Liu H, Zhang Y, Shen W Front Neurosci. 2023; 17:1123817.

PMID: 36937659 PMC: 10014821. DOI: 10.3389/fnins.2023.1123817.

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