Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2018 Jun 1

PMID 29850628

Citations 3

Authors

T N Sharapova

E A Romanova

L P Sashchenko

D V Yashin

Affiliations

Soon will be listed here.

Abstract

We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.

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References

Laouar Y, Crispe I . Functional flexibility in T cells: independent regulation of CD4+ T cell proliferation and effector function in vivo. Immunity. 2000; 13(3):291-301. DOI: 10.1016/s1074-7613(00)00029-7. View

Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Schmitz G . Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chaperones. 2001; 5(5):438-42. PMC: 312874. DOI: 10.1379/1466-1268(2000)005<0438:hpmeop>2.0.co;2. View

Michel T, Reichhart J, Hoffmann J, Royet J . Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature. 2001; 414(6865):756-9. DOI: 10.1038/414756a. View

Markel G, Lieberman N, Katz G, Arnon T, Lotem M, Drize O . CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J Immunol. 2002; 168(6):2803-10. DOI: 10.4049/jimmunol.168.6.2803. View

Appay V, Zaunders J, Papagno L, Sutton J, Jaramillo A, Waters A . Characterization of CD4(+) CTLs ex vivo. J Immunol. 2002; 168(11):5954-8. DOI: 10.4049/jimmunol.168.11.5954. View

Sashchenko L, Dukhanina E, Yashin D, Shatalov Y, Romanova E, Korobko E . Peptidoglycan recognition protein tag7 forms a cytotoxic complex with heat shock protein 70 in solution and in lymphocytes. J Biol Chem. 2003; 279(3):2117-24. DOI: 10.1074/jbc.M307513200. View

Walker M, Kasprowicz D, Gersuk V, Benard A, Van Landeghen M, Buckner J . Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest. 2003; 112(9):1437-43. PMC: 228469. DOI: 10.1172/JCI19441. View

Zaunders J, Dyer W, Wang B, Munier M, Miranda-Saksena M, Newton R . Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection. Blood. 2003; 103(6):2238-47. DOI: 10.1182/blood-2003-08-2765. View

Dziarski R . Peptidoglycan recognition proteins (PGRPs). Mol Immunol. 2003; 40(12):877-86. DOI: 10.1016/j.molimm.2003.10.011. View

10.

Larin S, Korobko E, Kustikova O, Borodulina O, Raikhlin N, Brisgalov I . Immunotherapy with autologous tumor cells engineered to secrete Tag7/PGRP, an innate immunity recognition molecule. J Gene Med. 2004; 6(7):798-808. DOI: 10.1002/jgm.560. View

11.

Bubenik J . MHC class I down-regulation: tumour escape from immune surveillance? (review). Int J Oncol. 2004; 25(2):487-91. View

12.

Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz T . Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity. 2004; 21(3):357-66. DOI: 10.1016/j.immuni.2004.06.020. View

13.

von Boehmer H . Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005; 6(4):338-44. DOI: 10.1038/ni1180. View

14.

Sakaguchi S . Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005; 6(4):345-52. DOI: 10.1038/ni1178. View

15.

Ferrarini M, Heltai S, Zocchi M, RUGARLI C . Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer. 1992; 51(4):613-9. DOI: 10.1002/ijc.2910510418. View

16.

Kunzmann V, Wilhelm M . Anti-lymphoma effect of gammadelta T cells. Leuk Lymphoma. 2005; 46(5):671-80. DOI: 10.1080/10428190500051893. View

17.

Yu K, Porcelli S . The diverse functions of CD1d-restricted NKT cells and their potential for immunotherapy. Immunol Lett. 2005; 100(1):42-55. DOI: 10.1016/j.imlet.2005.06.010. View

18.

Seliger B . Strategies of tumor immune evasion. BioDrugs. 2006; 19(6):347-54. DOI: 10.2165/00063030-200519060-00002. View

19.

Liu W, Putnam A, Xu-Yu Z, Szot G, Lee M, Zhu S . CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006; 203(7):1701-11. PMC: 2118339. DOI: 10.1084/jem.20060772. View

20.

Brutkiewicz R . CD1d ligands: the good, the bad, and the ugly. J Immunol. 2006; 177(2):769-75. DOI: 10.4049/jimmunol.177.2.769. View