Reovirus Serotype 1 Intestinal Infection: a Novel Replicative Cycle with Ileal Disease

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1985 Feb 1

PMID 2982027

Citations 48

Authors

D H Rubin

M J Kornstein

A O Anderson

Affiliations

Soon will be listed here.

Abstract

After oral inoculation, reovirus serotype 1 strain Lang was shown to specifically infect the epithelial cells of the ileum, while sparing the epithelial cells in the duodenum, jejunum, and colon. The initial site of replication was localized in cells of the crypts of Lieberkühn adjacent to Peyer's patches. Virus was subsequently found by immunoperoxidase staining in cells migrating up the crypt-villus complex throughout the ileum. The severity of the pathological changes in the ileum was proportional to the concentration of the viral inoculum. This site-specific infection of the ileum by reovirus may provide a model for diseases that are restricted to specific sites in the intestine.

Citing Articles

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Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.

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Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection.

Brown J, Short S, Stencel-Baerenwald J, Urbanek K, Pruijssers A, McAllister N J Virol. 2018; 92(10).

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Interactions between Enteric Bacteria and Eukaryotic Viruses Impact the Outcome of Infection.

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Bacteria and bacterial envelope components enhance mammalian reovirus thermostability.

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References

Blank H, Davis C, Collins C . Electron microscopy for the diagnosis of cutaneous viral infections. Br J Dermatol. 1970; 83:Suppl:69-80. DOI: 10.1111/j.1365-2133.1970.tb12866.x. View

Kornstein M, Brooks J, Elder D . Immunoperoxidase localization of lymphocyte subsets in the host response to melanoma and nevi. Cancer Res. 1983; 43(6):2749-53. View

Bangaru B, MORECKI R, Glaser J, GARTNER L, Horwitz M . Comparative studies of biliary atresia in the human newborn and reovirus-induced cholangitis in weanling mice. Lab Invest. 1980; 43(5):456-62. View

Rosen L . Serologic grouping of reoviruses by hemagglutination-inhibition. Am J Hyg. 1960; 71:242-9. DOI: 10.1093/oxfordjournals.aje.a120107. View

Abrams J . Experimental intestinal atresia. Surgery. 1968; 64(1):185-91. View

Rosen L, ABINANTI F . Natural and experimental infection of catle with human types of reoviruses. Am J Hyg. 1960; 71:250-7. DOI: 10.1093/oxfordjournals.aje.a120108. View

Tardieu M, POWERS M, Weiner H . Age dependent susceptibility to Reovirus type 3 encephalitis: role of viral and host factors. Ann Neurol. 1983; 13(6):602-7. DOI: 10.1002/ana.410130604. View

Kauffman R, Wolf J, Finberg R, Trier J, Fields B . The sigma 1 protein determines the extent of spread of reovirus from the gastrointestinal tract of mice. Virology. 1983; 124(2):403-10. DOI: 10.1016/0042-6822(83)90356-2. View

Rubin D, Fields B . Molecular basis of reovirus virulence. Role of the M2 gene. J Exp Med. 1980; 152(4):853-68. PMC: 2185979. DOI: 10.1084/jem.152.4.853. View

10.

Ahmed R, GRAHAM A . Persistent infections in L cells with temperature-sensitive mutants of reovirus. J Virol. 1977; 23(2):250-62. PMC: 515827. DOI: 10.1128/JVI.23.2.250-262.1977. View

11.

MORECKI R, Glaser J, Cho S, Balistreri W, Horwitz M . Biliary atresia and reovirus type 3 infection. N Engl J Med. 1982; 307(8):481-4. DOI: 10.1056/NEJM198208193070806. View

12.

Ramig R, Cross R, Fields B . Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3. J Virol. 1977; 22(3):726-33. PMC: 515772. DOI: 10.1128/JVI.22.3.726-733.1977. View

13.

Owen R . Macrophage function in Peyer's patch epithelium. Adv Exp Med Biol. 1982; 149:507-13. DOI: 10.1007/978-1-4684-9066-4_71. View

14.

Schreiber D, Trier J, Blacklow N . Recent advances in viral gastroenteritis. Gastroenterology. 1977; 73(1):174-83. PMC: 7130306. View

15.

Sanford B, Davison V, Ramsay M . Fibrinogen-mediated adherence of group A Streptococcus to influenza A virus-infected cell cultures. Infect Immun. 1982; 38(2):513-20. PMC: 347768. DOI: 10.1128/iai.38.2.513-520.1982. View

16.

Delorimier A, Fonkalsrud E, Hays D . Congenital atresia and stenosis of the jejunum and ileum. Surgery. 1969; 65(5):819-27. View

17.

Weiser M . Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. J Biol Chem. 1973; 248(7):2536-41. View

18.

Richman D, Murphy B . The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines. Rev Infect Dis. 1979; 1(3):413-33. DOI: 10.1093/clinids/1.3.413. View

19.

HOWE H, BODIAN D, MORGAN I . Subclinical poliomyelitis in the chimpanzee and its relation to alimentary reinfection. Am J Hyg. 1950; 51(1):85-108, tab. DOI: 10.1093/oxfordjournals.aje.a119379. View

20.

Wolf J, Kauffman R, Finberg R, Dambrauskas R, Fields B, Trier J . Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine. Gastroenterology. 1983; 85(2):291-300. View