» Articles » PMID: 29808242

[CEUS-application Possibilities in the Musculoskeletal System]

Overview
Journal Radiologe
Specialty Radiology
Date 2018 May 30
PMID 29808242
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Methodical Issue: Contrast-enhanced ultrasound (CEUS) offers easily accessible visualization and quantification of the skeletal muscle microcirculation and other tissues in vivo and in real-time with almost no side effects.

Aim: The aim of this review is to present the increasing number of musculoskeletal CEUS applications.

Methodical Innovations/performance: CEUS applications regarding the musculoskeletal system include applications at bone and joints extending beyond the visualization of only the muscular microcirculation. Besides basic muscle physiology, impaired microcirculation in patients with peripheral artery disease or diabetes mellitus and the diagnosis of inflammatory myopathies have been the subject of previous CEUS studies. More recent studies in orthopedics and traumatology have focused on osseous and muscular perfusion characteristics, e. g., in differentiating infected and aseptic non-unions or the impact of different types of implants and prostheses on muscular microcirculation as a surrogate marker of clinical success.

Practical Recommendations: CEUS of the musculoskeletal system is used in clinical trials or off-label. Therefore, it is not well established in clinical routine. However, considering the increasing number of musculoskeletal CEUS applications, this could change in the future.

Citing Articles

Quantitative Analysis of Contrast-Enhanced Ultrasound That Can Be Used to Evaluate Angiogenesis during Patellar Tendon Healing in Rats.

Zhao H, Sheng D, Cai Y, Tang Y, Li M, Chen J Contrast Media Mol Imaging. 2022; 2022:6867743.

PMID: 36313964 PMC: 9584743. DOI: 10.1155/2022/6867743.


Applications of Contrast-Enhanced Ultrasound in Splenic Studies of Dogs and Cats.

Canejo-Teixeira R, Lima A, Santana A Animals (Basel). 2022; 12(16).

PMID: 36009694 PMC: 9404716. DOI: 10.3390/ani12162104.


A Preliminary Study of Contrast-Enhanced Ultrasound (CEUS) and Cytokine Expression Analysis (CEA) as Early Predictors for the Outcome of Tibial Non-Union Therapy.

Haubruck P, Heller R, Tanner M, Daniel V, Schmidmaier G, Bolourchi F Diagnostics (Basel). 2018; 8(3).

PMID: 30149501 PMC: 6164610. DOI: 10.3390/diagnostics8030055.


[Contrast-enhanced ultrasound: Tingling].

Delorme S, Clevert D Radiologe. 2018; 58(6):519-520.

PMID: 29797042 DOI: 10.1007/s00117-018-0396-2.

References
1.
Mitchell W, Phillips B, Williams J, Rankin D, Smith K, Lund J . Development of a new Sonovue™ contrast-enhanced ultrasound approach reveals temporal and age-related features of muscle microvascular responses to feeding. Physiol Rep. 2013; 1(5):e00119. PMC: 3841050. DOI: 10.1002/phy2.119. View

2.
Weber M, Krix M, Jappe U, Huttner H, Hartmann M, Meyding-Lamade U . Pathologic skeletal muscle perfusion in patients with myositis: detection with quantitative contrast-enhanced US--initial results. Radiology. 2005; 238(2):640-9. DOI: 10.1148/radiol.2382041822. View

3.
Amarteifio E, Wormsbecher S, Demirel S, Krix M, Braun S, Rehnitz C . Assessment of skeletal muscle microcirculation in type 2 diabetes mellitus using dynamic contrast-enhanced ultrasound: a pilot study. Diab Vasc Dis Res. 2013; 10(5):468-70. DOI: 10.1177/1479164113484165. View

4.
Hildebrandt W, Schwarzbach H, Pardun A, Hannemann L, Bogs B, Konig A . Age-related differences in skeletal muscle microvascular response to exercise as detected by contrast-enhanced ultrasound (CEUS). PLoS One. 2017; 12(3):e0172771. PMC: 5342194. DOI: 10.1371/journal.pone.0172771. View

5.
Piscaglia F, Nolsoe C, Dietrich C, Cosgrove D, Gilja O, Bachmann Nielsen M . The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med. 2011; 33(1):33-59. DOI: 10.1055/s-0031-1281676. View