Long Non-coding RNA Regulates Viability and Metastasis, and is Upregulated in Retinoblastoma

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 May 29

PMID 29805578

Citations 9

Authors

Li Li

Wei Chen

Yuchuan Wang

Luosheng Tang

Mei Han

Affiliations

Soon will be listed here.

Abstract

Retinoblastoma is the most common type of intraocular pediatric malignant tumor, which typically affects children <6 years of age. However, the underlying molecular mechanisms of retinoblastoma progression remain unclear. The aim of the present study was to investigate the function of long non-coding RNA (lncRNA) in retinoblastoma clinical samples and cell lines, using reverse transcription-quantitative polymerase chain reaction, western blotting, colony formation, MTT, fluorescence activated cell sorting, cell invasion and migration, and growth assays. The results demonstrated that may serve a critical oncogenic function in the progression of retinoblastoma, as lncRNA levels were markedly increased in retinoblastoma cells and tissues compared with corresponding controls. In addition, patients with retinoblastoma with increased lncRNA expression experienced poorer survival time compared with those with decreased lncRNA levels. Knockdown of lncRNA significantly suppressed retinoblastoma cell proliferation, migration and invasion and . Furthermore, lncRNA expression was also associated with multiple proteins, including cyclin-dependent kinase 1, B-cell lymphoma-associated X protein, apoptosis regulator, tumor protein p53, vimentin, cadherin 13 and matrix metallopeptidase 9. In conclusion, lncRNA may serve an important function in tumorigenesis and may be a potential target for therapy and prognosis in retinoblastoma.

Citing Articles

Applications of Non-Coding RNAs in Patients With Retinoblastoma.

Fernandez-Diaz D, Rodriguez-Vidal C, Silva-Rodriguez P, Paniagua L, Blanco-Teijeiro M, Pardo M Front Genet. 2022; 13:842509.

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LncRNA H19: A novel oncogene in multiple cancers.

Yang J, Qi M, Fei X, Wang X, Wang K Int J Biol Sci. 2021; 17(12):3188-3208.

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Long noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis.

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XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma.

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