The Link Between Potassium and Mild Cognitive Impairment in Mexican-Americans

Overview

Journal Dement Geriatr Cogn Dis Extra

Publisher Karger

Specialty Geriatrics

Date 2018 May 29

PMID 29805381

Citations 10

Authors

Raul M Vintimilla

Stephanie E Large

Adriana Gamboa

Geoffrey D Rohlfing

Judith R OJile

James R Hall

Sid E OBryant

Leigh A Johnson

Affiliations

Soon will be listed here.

Abstract

Background: Recent evidence suggests that increasing dietary intake of minerals reduces the risk of dementia. This study aimed to examine the relationship between potassium and diagnosis of mild cognitive impairment (MCI) in a sample of older Mexican-Americans from rural and urban populations.

Methods: The sample was formed of a total of 139 participants with MCI and 371 normal controls from two independent cohorts: a rural cohort (Facing Rural Obstacles to Healthcare Now through Intervention, Education and Research [Project FRONTIER]) and an urban cohort (the Health and Aging Brain among Latino Elders [HABLE] study). Serum electrolytes examined were sodium and potassium. Age and education were entered in the model as covariates.

Results: Across both cohorts, the Project FRONTIER (OR = 3.1; = 0.01) and the HABLE Project (OR = 2.0; = 0.04), the results indicated that serum potassium levels significantly increased the risk of diagnosis of MCI.

Conclusion: Our finding suggested a link between serum potassium levels and a diagnosis of MCI in Mexican-Americans. The results of this study support a previous research which has suggested that the risk factors for MCI may vary by ethnicity.

Citing Articles

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Dong B, He M, Ji S, Yang W, Hong Q, Tang Y Sci Rep. 2025; 15(1):7700.

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Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease.

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Overlooked cases of mild cognitive impairment: Implications to early Alzheimer's disease.

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Higher intake of certain nutrients among older adults is associated with better cognitive function: an analysis of NHANES 2011-2014.

Devarshi P, Gustafson K, Grant R, Hazels Mitmesser S BMC Nutr. 2023; 9(1):142.

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Metals in Alzheimer's Disease.

Babic Leko M, Langer Horvat L, Spanic Popovacki E, Zubcic K, Hof P, Simic G Biomedicines. 2023; 11(4).

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References

Jackson J, Doescher M, Jerant A, Hart L . A national study of obesity prevalence and trends by type of rural county. J Rural Health. 2005; 21(2):140-8. DOI: 10.1111/j.1748-0361.2005.tb00074.x. View

Hill J, You W, Zoellner J . Disparities in obesity among rural and urban residents in a health disparate region. BMC Public Health. 2014; 14:1051. PMC: 4198673. DOI: 10.1186/1471-2458-14-1051. View

Patterson P, Moore C, Probst J, Shinogle J . Obesity and physical inactivity in rural America. J Rural Health. 2004; 20(2):151-9. DOI: 10.1111/j.1748-0361.2004.tb00022.x. View

Cisternas P, Lindsay C, Salazar P, Silva-Alvarez C, Retamales R, Serrano F . The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease. Biochim Biophys Acta. 2015; 1852(12):2630-44. DOI: 10.1016/j.bbadis.2015.09.009. View

Cherbuin N, Kumar R, Sachdev P, Anstey K . Dietary Mineral Intake and Risk of Mild Cognitive Impairment: The PATH through Life Project. Front Aging Neurosci. 2014; 6:4. PMC: 3912433. DOI: 10.3389/fnagi.2014.00004. View

OBryant S, Johnson L, Balldin V, Edwards M, Barber R, Williams B . Characterization of Mexican Americans with mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2012; 33(2):373-9. PMC: 3524411. DOI: 10.3233/JAD-2012-121420. View

Satia-Abouta J, Patterson R, Neuhouser M, Elder J . Dietary acculturation: applications to nutrition research and dietetics. J Am Diet Assoc. 2002; 102(8):1105-18. DOI: 10.1016/s0002-8223(02)90247-6. View

Tian N, Zhang Z, Loustalot F, Yang Q, Cogswell M . Sodium and potassium intakes among US infants and preschool children, 2003-2010. Am J Clin Nutr. 2013; 98(4):1113-22. PMC: 4559260. DOI: 10.3945/ajcn.113.060012. View

Meng X, Yu J, Wang H, Tan M, Wang C, Tan C . Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014; 42(4):1295-310. DOI: 10.3233/JAD-140954. View

10.

Wang Z, Manichukal A, Goff Jr D, Mora S, Ordovas J, Pajewski N . Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA). Hum Genet. 2017; 136(6):715-726. PMC: 5429342. DOI: 10.1007/s00439-017-1782-y. View

11.

Goslar P, Macera C, Castellanos L, Hussey J, Sy F, Sharpe P . Blood pressure in Hispanic women: the role of diet, acculturation, and physical activity. Ethn Dis. 1997; 7(2):106-13. View

12.

Haring B, Wu C, Coker L, Seth A, Snetselaar L, Manson J . Hypertension, Dietary Sodium, and Cognitive Decline: Results From the Women's Health Initiative Memory Study. Am J Hypertens. 2015; 29(2):202-16. PMC: 4723668. DOI: 10.1093/ajh/hpv081. View

13.

. 2016 Alzheimer's disease facts and figures. Alzheimers Dement. 2016; 12(4):459-509. DOI: 10.1016/j.jalz.2016.03.001. View

14.

Gregory-Mercado K, Staten L, Gillespie C, Ranger-Moore J, Thomson C, Giuliano A . Ethnicity and nutrient intake among Arizona WISEWOMAN participants. J Womens Health (Larchmt). 2007; 16(3):379-89. DOI: 10.1089/jwh.2006.M078. View

15.

Bischof G, Park D . Obesity and Aging: Consequences for Cognition, Brain Structure, and Brain Function. Psychosom Med. 2015; 77(6):697-709. PMC: 5648343. DOI: 10.1097/PSY.0000000000000212. View

16.

Petersen R . Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004; 256(3):183-94. DOI: 10.1111/j.1365-2796.2004.01388.x. View

17.

Clarke P, Weuve J, Barnes L, Evans D, Mendes de Leon C . Cognitive decline and the neighborhood environment. Ann Epidemiol. 2015; 25(11):849-54. PMC: 4609590. DOI: 10.1016/j.annepidem.2015.07.001. View

18.

Park Y, Neckerman K, Quinn J, Weiss C, Jacobson J, Rundle A . Neighbourhood immigrant acculturation and diet among Hispanic female residents of New York City. Public Health Nutr. 2011; 14(9):1593-600. PMC: 3696981. DOI: 10.1017/S136898001100019X. View

19.

Fenwick E, Man R, Cheung C, Sabanayagam C, Cheng C, Neelam K . Ethnic Differences in the Association Between Age-Related Macular Degeneration and Vision-Specific Functioning. JAMA Ophthalmol. 2017; 135(5):469-476. PMC: 5470419. DOI: 10.1001/jamaophthalmol.2017.0266. View

20.

OBryant S, Hall J, Cukrowicz K, Edwards M, Johnson L, Lefforge D . The differential impact of depressive symptom clusters on cognition in a rural multi-ethnic cohort: a Project FRONTIER study. Int J Geriatr Psychiatry. 2010; 26(2):199-205. DOI: 10.1002/gps.2514. View