Potential Use of Pentoxifylline in Cancer Therapy

Overview

Journal Curr Pharm Biotechnol

Publisher Bentham Science Publishers

Specialties Biotechnology
Pharmacology

Date 2018 May 29

PMID 29804530

Citations 11

Authors

Grzegorz Golunski

Anna Woziwodzka

Jacek Piosik

Affiliations

Soon will be listed here.

Abstract

Background: Pentoxifylline (PTX) is a drug commonly used in the treatment of intermittent claudication. However, numerous research groups report that PTX also may potentially be used in the anticancer therapy following one of the main trends in the nowadays medicine - combined anticancer therapy.

Scope Of Review: The review concentrates on the reports revealing the potential use of PTX in cancer treatment. Major Conclusion: PTX is described to possess several properties which may be exploited in cancer treatment. The drug reportedly not only has anticancer activity itself, but also increases cancer cells susceptibility to radiation therapy and, additionally, reduces long-term side effects of this therapy. Furthermore, numerous research groups report that PTX may increase the anticancer potential of commonly used anticancer drugs such as cisplatin or doxorubicin as well as reduce side effects of these drugs.

Significance: PTX should be considered as a potential drug in the combined anticancer therapy.

Citing Articles

Improvement of Docetaxel Efficacy through Simultaneous Blockade of Transcription Factors NF-κB and STAT-3 Using Pentoxifylline and Stattic in Prostate Cancer Cells.

Cruz-Lozano J, Hernandez-Flores G, Ortiz-Lazareno P, Palafox-Mariscal L, Vazquez-Ibarra K, Gonzalez-Martinez K Curr Issues Mol Biol. 2024; 46(9):10140-10159.

PMID: 39329957 PMC: 11431379. DOI: 10.3390/cimb46090605.

Pentoxifylline and Norcantharidin Modify p62 Expression in 2D and 3D Cultures of B16F1 Cells.

Gonzalez-Quiroz J, Ocampo-Godinez J, Hernandez-Gonzalez V, Lezama R, Reyes-Maldonado E, Vega-Lopez A Int J Mol Sci. 2024; 25(10).

PMID: 38791178 PMC: 11121437. DOI: 10.3390/ijms25105140.

Tumor-Infiltrating iNKT Cells Activated through c-Kit/Sca-1 Are Induced by Pentoxifylline, Norcantharidin, and Their Mixtures for Killing Murine Melanoma Cells.

Correa-Lara M, Lara-Vega I, Najera-Martinez M, Dominguez-Lopez M, Reyes-Maldonado E, Vega-Lopez A Pharmaceuticals (Basel). 2023; 16(10).

PMID: 37895943 PMC: 10610189. DOI: 10.3390/ph16101472.

Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids.

Cioce M, Fumagalli M, Donzelli S, Goeman F, Canu V, Rutigliano D J Exp Clin Cancer Res. 2023; 42(1):170.

PMID: 37460938 PMC: 10351152. DOI: 10.1186/s13046-023-02754-6.

Pentoxifylline changes the balance of immune cell population in breast tumor-infiltrating lymphocytes.

Kazemi M, Shokrollahi Barough M, Momeni-Varposhti Z, Ghanavatinejad A, Zarehzadeh Mehrabadi A, Sadeghi B Med Oncol. 2023; 40(6):168.

PMID: 37149505 PMC: 10164001. DOI: 10.1007/s12032-023-02034-5.