Reduced Gray Matter Volume and Respiratory Dysfunction in Parkinson's Disease: a Voxel-based Morphometry Study

Overview

Journal BMC Neurol

Publisher Biomed Central

Specialty Neurology

Date 2018 May 28

PMID 29803228

Citations 11

Authors

Sieh-Yang Lee

Meng-Hsiang Chen

Pi-Ling Chiang

Hsiu-Ling Chen

Kun-Hsien Chou

Yueh-Cheng Chen

Chiun-Chieh Yu

Nai-Wen Tsai

Shau-Hsuan Li

Cheng-Hsien Lu

Wei-Che Lin

Affiliations

Soon will be listed here.

Abstract

Background: The respiratory dysfunction of patients with Parkinson's disease (PD) has drawn increasing attention. This study evaluated the relationship between gray matter volume (GMV), as determined by voxel-based morphometry (VBM), and respiratory dysfunction in patients with PD and correlated it with systemic inflammatory markers.

Methods: Whole-brain VBM analysis was performed on 3-dimensional T1-weighted images in 25 PD patients with abnormal pulmonary function (13 men, 12 women; mean age: 62.9 ± 10.8 years) and, for comparison, on 25 sex- and age-matched PD patients with normal pulmonary function (14 men, 11 women; mean age: 62.3 ± 6.9 years). Inflammatory markers were determined by flow cytometry. The differences and correlations in regional GMV, clinical severity and inflammatory markers were determined after adjusting for age, gender and total intracranial volume (TIV).

Results: Compared with the normal pulmonary function group, the abnormal pulmonary function group had smaller GMV in several brain regions, including the left parahippocampal formation, right fusiform gyrus, right cerebellum crus, and left postcentral gyri. Forced expiratory volume in 1 s (FEV1) and maximal expiratory flow after expiration of 50% of forced vital capacity (MEF50) were positively correlated with regional GMV. There were no significant differences in the level of serum inflammatory markers between two groups.

Conclusion: Our findings suggested that involvement of the central autonomic network and GM loss may underlie the respiratory dysfunction in PD patients.

Citing Articles

Multimodal Magnetic Resonance Findings in Parkinson's Disease With "Antecedent Essential Tremor": A Case Series of a Large Kindred.

Kong Y, Yao L, Xiao X, Chen A, Wang K, Yan H Neuropsychiatr Dis Treat. 2025; 21:79-92.

PMID: 39871882 PMC: 11769848. DOI: 10.2147/NDT.S498644.

Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier.

Yang C, Liu G, Chen X, Le W MedComm (2020). 2024; 5(7):e638.

PMID: 39006764 PMC: 11245631. DOI: 10.1002/mco2.638.

Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons.

Murrieta-Alvarez I, A Fernandez-Gutierrez J, Perez C, Leon-Pena A, Reyes-Cisneros O, Benitez-Salazar J Neurol Sci. 2023; 44(12):4429-4439.

PMID: 37410269 DOI: 10.1007/s10072-023-06914-6.

Respiratory Abnormalities in Parkinson's Disease: What Do We Know from Studies in Humans and Animal Models?.

Kaczynska K, Orlowska M, Andrzejewski K Int J Mol Sci. 2022; 23(7).

PMID: 35408858 PMC: 8998219. DOI: 10.3390/ijms23073499.

Parkinson's disease, treatment choice and survival over time.

Tvete I, Klemp M Clin Park Relat Disord. 2022; 6:100136.

PMID: 35146410 PMC: 8816715. DOI: 10.1016/j.prdoa.2022.100136.

References

Hughes A, Daniel S, Kilford L, Lees A . Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992; 55(3):181-4. PMC: 1014720. DOI: 10.1136/jnnp.55.3.181. View

HOEHN M, Yahr M . Parkinsonism: onset, progression and mortality. Neurology. 1967; 17(5):427-42. DOI: 10.1212/wnl.17.5.427. View

Yust-Katz S, Shitrit D, Melamed E, Djaldetti R . Respiratory distress: an unrecognized non-motor phenomenon in patients with parkinsonism. J Neural Transm (Vienna). 2011; 119(1):73-6. DOI: 10.1007/s00702-011-0671-0. View

Thyagarajan B, Smith L, Barr R, Gross M, Sood A, Kalhan R . Association of circulating adhesion molecules with lung function. The CARDIA study. Chest. 2009; 135(6):1481-1487. PMC: 2821290. DOI: 10.1378/chest.08-1753. View

Seccombe L, Giddings H, Rogers P, Corbett A, Hayes M, Peters M . Abnormal ventilatory control in Parkinson's disease--further evidence for non-motor dysfunction. Respir Physiol Neurobiol. 2011; 179(2-3):300-4. DOI: 10.1016/j.resp.2011.09.012. View

Wang Q, Wu Q, Feng J, Sun X . Obstructive sleep apnea and endothelial progenitor cells. Patient Prefer Adherence. 2013; 7:1077-90. PMC: 3804572. DOI: 10.2147/PPA.S51562. View

Guder G, Brenner S, Stork S, Held M, Broekhuizen B, Lammers J . Diagnostic and prognostic utility of mid-expiratory flow rate in older community-dwelling persons with respiratory symptoms, but without chronic obstructive pulmonary disease. BMC Pulm Med. 2015; 15:83. PMC: 4521503. DOI: 10.1186/s12890-015-0081-4. View

Yip H, Chang L, Chang W, Lu C, Liou C, Lan M . Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke. Stroke. 2007; 39(1):69-74. DOI: 10.1161/STROKEAHA.107.489401. View

Evans K . Cortico-limbic circuitry and the airways: insights from functional neuroimaging of respiratory afferents and efferents. Biol Psychol. 2010; 84(1):13-25. PMC: 2908728. DOI: 10.1016/j.biopsycho.2010.02.005. View

10.

Corfield D, Fink G, Ramsay S, Murphy K, Harty H, Watson J . Evidence for limbic system activation during CO2-stimulated breathing in man. J Physiol. 1995; 488 ( Pt 1):77-84. PMC: 1156702. DOI: 10.1113/jphysiol.1995.sp020947. View

11.

Ashburner J . A fast diffeomorphic image registration algorithm. Neuroimage. 2007; 38(1):95-113. DOI: 10.1016/j.neuroimage.2007.07.007. View

12.

Zhang H, Wang X, Lin J, Sun Y, Huang Y, Yang T . Reduced regional gray matter volume in patients with chronic obstructive pulmonary disease: a voxel-based morphometry study. AJNR Am J Neuroradiol. 2012; 34(2):334-9. PMC: 7965120. DOI: 10.3174/ajnr.A3235. View

13.

Miller M, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A . Standardisation of spirometry. Eur Respir J. 2005; 26(2):319-38. DOI: 10.1183/09031936.05.00034805. View

14.

Obeso J, Rodriguez-Oroz M, Rodriguez M, Lanciego J, Artieda J, Gonzalo N . Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci. 2000; 23(10 Suppl):S8-19. DOI: 10.1016/s1471-1931(00)00028-8. View

15.

Benarroch E . The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc. 1993; 68(10):988-1001. DOI: 10.1016/s0025-6196(12)62272-1. View

16.

Wanger J, Clausen J, Coates A, Pedersen O, Brusasco V, Burgos F . Standardisation of the measurement of lung volumes. Eur Respir J. 2005; 26(3):511-22. DOI: 10.1183/09031936.05.00035005. View

17.

Chen H, Lu C, Lin H, Chen P, Chou K, Lin W . White matter damage and systemic inflammation in obstructive sleep apnea. Sleep. 2014; 38(3):361-70. PMC: 4335530. DOI: 10.5665/sleep.4490. View

18.

Zinellu A, Fois A, Sotgia S, Zinellu E, Bifulco F, Pintus G . Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease. Eur J Clin Invest. 2015; 46(2):181-8. DOI: 10.1111/eci.12582. View

19.

Weng H, Tsai Y, Chen C, Lin Y, Yang C, Tsai Y . Mapping gray matter reductions in obstructive sleep apnea: an activation likelihood estimation meta-analysis. Sleep. 2014; 37(1):167-75. PMC: 3902879. DOI: 10.5665/sleep.3330. View

20.

Wang H, Lin W, Lin Y, Rau C, Lee T, Chang W . The association between serum adhesion molecules and outcome in acute spontaneous intracerebral hemorrhage. Crit Care. 2011; 15(6):R284. PMC: 3388671. DOI: 10.1186/cc10568. View