Isolation of Rat Olfactory Ensheathing Cells and Their Use in the Therapy of Posttraumatic Cysts of the Spinal Cord

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2018 May 26

PMID 29796806

Citations 7

Authors

O V Stepanova

A D Voronova

A V Chadin

M P Valikhov

M A Abakumov

I V Reshetov

V P Chekhonin

Affiliations

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Abstract

We evaluated the efficacy of rat olfactory ensheathing cells in the therapy of experimental cysts of the spinal cord. Improvement of the motor function of the hind limbs after transplantation of the olfactory ensheathing cells into the posttraumatic spinal cord cysts rats was found. We also determined the required number of cells for transplantation and demonstrated a neuroprotective effect of this dosage. For further clinical studies, autologous tissue-specific cell preparation of olfactory ensheathing cells has to be created. Cell therapy in combination surgical and pharmacological treatment will substantially improve the quality of life of patients with posttraumatic spinal cord cysts.

Citing Articles

The Use of Neurotrophic Factors as a Promising Strategy for the Treatment of Neurodegenerative Diseases (Review).

Fursa G, Andretsova S, Shishkina V, Voronova A, Karsuntseva E, Chadin A Bull Exp Biol Med. 2024; 177(4):517-527.

PMID: 39266924 DOI: 10.1007/s10517-024-06218-5.

Modeling of Alzheimer's Disease to Study the Efficacy of Cell Therapy (Review).

Voronova A, Karsuntseva E, Stepanova O, Chadin A, Shishkina V, Andretsova S Bull Exp Biol Med. 2023; 175(4):524-529.

PMID: 37768457 DOI: 10.1007/s10517-023-05899-8.

Application of Behavioral Tests for Evaluation of an Experimental Model of Alzheimer's Disease in Female Rats.

Karsuntseva E, Voronova A, Chadin A, Shishkina V, Fursa G, Andretsova S Bull Exp Biol Med. 2023; 175(1):126-131.

PMID: 37336813 DOI: 10.1007/s10517-023-05823-0.

Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries.

Stepanova O, Fursa G, Andretsova S, Shishkina V, Voronova A, Chadin A World J Clin Cases. 2023; 11(2):322-331.

PMID: 36686356 PMC: 9850961. DOI: 10.12998/wjcc.v11.i2.322.

Application of a New Gene-Cell Construct Based on the Olfactory Mucosa Escheating Cells Transduced with an Adenoviral Vector Encoding Mature BDNF in the Therapy of Spinal Cord Cysts.

Karsuntseva E, Fursa G, Sosnovtseva A, Voronova A, Chadin A, Semkina A Bull Exp Biol Med. 2022; 172(5):617-621.

PMID: 35352253 DOI: 10.1007/s10517-022-05446-x.