Increased Serum Interleukin-37 (IL-37) Levels Correlate with Oxidative Stress Parameters in Hashimoto's Thyroiditis

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 2018 May 26

PMID 29796799

Citations 13

Authors

R M Ruggeri

M Cristani

T M Vicchio

A Alibrandi

S Giovinazzo

A Saija

A Campenni

F Trimarchi

S Gangemi

Affiliations

Soon will be listed here.

Abstract

Purpose: Interleukin-37 (IL-37), member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves' disease. To our knowledge, no data on Hashimoto's thyroiditis (HT) are available in the literature.

Methods: Aim of our study was to measure serum IL-37 levels and evaluate their relationship, if any, with oxidative stress markers in HT patients. We enrolled 45 euthyroid HT patients (5 M e 40 F, median age 40 years) and 50 age- and sex-matched healthy controls. None was under L-thyroxine therapy. Serum IL-37 levels were measured by ELISA. Specific serum tests, such as derived reactive oxygen metabolites (d-ROMs), and biological anti-oxidant potential (BAP) test were performed in all subjects to investigate the changes in oxidative balance, and advanced glycation end products (AGEs) were determined as a specific marker of oxidative stress.

Results: IL-37 levels were significantly higher in HT than in controls (median 475 vs. 268 pg/ml, P = 0.018). In the same patients, serum oxidants (d-ROMs) were increased and anti-oxidants (BAP) decreased compared with controls (P = 0.011 and < 0.0001, respectively), clearly indicating an enhanced oxidative stress. In addition, AGEs levels were higher in HT patients than in controls (210 vs. 140 AU/g prot, P < 0.0001) and directly correlated with IL-37 levels (P = 0.048). At multivariate analysis, the main independent predictors that influenced IL-37 levels were both anti-thyroid antibodies (P = 0.026) and AGEs levels (P = 0.001).

Conclusions: IL-37 is up-regulated in HT and may exert a protective role by counteracting oxidative stress and inflammation.

Citing Articles

Do Dietary Supplements Affect Inflammation, Oxidative Stress, and Antioxidant Status in Adults with Hypothyroidism or Hashimoto's Disease?-A Systematic Review of Controlled Trials.

Kubiak K, Szmidt M, Kaluza J, Zylka A, Sicinska E Antioxidants (Basel). 2023; 12(10).

PMID: 37891878 PMC: 10604871. DOI: 10.3390/antiox12101798.

The Influence of Food Regimes on Oxidative Stress: A Permutation-Based Approach Using the NPC Test.

Zirilli A, Ruggeri R, Barbalace M, Hrelia S, Giovanella L, Campenni A Healthcare (Basel). 2023; 11(16).

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Advanced glycation end products and their soluble receptor (sRAGE) in patients with Hashimoto's thyroiditis on levothyroxine substitution.

Csiha S, Molnar I, Halmi S, Hutkai D, Lorincz H, Somodi S Front Endocrinol (Lausanne). 2023; 14:1187725.

PMID: 37305044 PMC: 10250717. DOI: 10.3389/fendo.2023.1187725.

IL‑37 suppresses macrophage ferroptosis to attenuate diabetic atherosclerosis via the NRF2 pathway.

Xu J, Han X, Xia N, Zhao Q, Cheng Z Exp Ther Med. 2023; 25(6):289.

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Associations between empirically derived dietary patterns and oxidative stress and inflammation in adults with primary hypothyroidism: a case-control study.

Taherinia S, Heidari Z, Salehidoost R, Karimifar M, Arab A, Alshahrani S BMC Endocr Disord. 2023; 23(1):105.

PMID: 37161471 PMC: 10170704. DOI: 10.1186/s12902-023-01348-9.

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