Trans-chalcone Enhances Insulin Sensitivity Through the MiR-34a/SIRT1 Pathway

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2018 May 26

PMID 29796217

Citations 5

Authors

Elham Karimi-Sales

Sajad Jeddi

Abbas Ebrahimi-Kalan

Mohammad Reza Alipour

Affiliations

Soon will be listed here.

Abstract

Objectives: Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of trans-chalcone on the miR-34a/SIRT1 pathway as a possible mechanism for its hypoglycemic and hypoinsulinemic effects.

Materials And Methods: In this study, thirty male rats were randomly divided into three groups (n=10): solvent control (NS), oral administration of trans-chalcone for 2 (N2T) and 6 weeks (N6T) groups. Then, hepatic levels of miR-34a and SIRT1 were measured through the qRT-PCR method.

Results: Trans-chalcone reduced food intake, body weight gain, and serum glucose as well as insulin levels. Also, this chalcone inhibited hepatic miR-34a expression and significantly elevated SIRT1 mRNA level.

Conclusion: Trans-chalcone as an insulin-sensitizing chalcone partly acts through the miR-34a/SIRT1 pathway.

Citing Articles

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PMID: 38150313 PMC: 10752418. DOI: 10.1289/EHP12785.

Anti-angiogenic Potential of Trans-chalcone in an Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability.

Senrung A, Tripathi T, Aggarwal N, Janjua D, Chhokar A, Yadav J Cardiovasc Hematol Agents Med Chem. 2023; 22(2):187-211.

PMID: 37936455 DOI: 10.2174/0118715257250417231019102501.

Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451.

Karimi-Sales E, Jeddi S, Ebrahimi-Kalan A, Alipour M Adv Pharm Bull. 2022; 12(1):200-205.

PMID: 35517895 PMC: 9012929. DOI: 10.34172/apb.2022.022.

Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism.

Huang X, Shi Y, Chen H, Le R, Gong X, Xu K Cell Death Dis. 2020; 11(12):1040.

PMID: 33288747 PMC: 7721869. DOI: 10.1038/s41419-020-03260-9.

Protective Effect of Trans-chalcone Against High-Fat Diet-Induced Pulmonary Inflammation Is Associated with Changes in miR-146a And pro-Inflammatory Cytokines Expression in Male Rats.

Karimi-Sales E, Alipour M, Naderi R, Hosseinzadeh E, Ghiasi R Inflammation. 2019; 42(6):2048-2055.

PMID: 31473901 DOI: 10.1007/s10753-019-01067-1.

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