The UCP2 -866G/A, Ala55Val and UCP3 -55C/T Polymorphisms Are Associated with Premature Coronary Artery Disease and Cardiovascular Risk Factors in Mexican Population

Overview

Journal Genet Mol Biol

Specialty Genetics

Date 2018 May 23

PMID 29786102

Citations 5

Authors

Ricardo Gamboa

Claudia Huesca-Gomez

Vanessa Lopez-Perez

Rosalinda Posadas-Sanchez

Guillermo Cardoso-Saldana

Aida Medina-Urrutia

Juan Gabriel Juarez-Rojas

Maria Elena Soto

Carlos Posadas-Romero

Gilberto Vargas-Alarcon

Affiliations

Soon will be listed here.

Abstract

We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors.

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