CoCrMo Alloy . UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses Using a Murine Model

Overview

Journal Open Orthop J

Publisher Bentham Open

Specialty Orthopedics

Date 2018 May 23

PMID 29785221

Citations 4

Authors

Stefan Landgraeber

Lauryn Samelko

Kyron McAllister

Sebastian Putz

Joshua J Jacobs

Nadim James Hallab

Affiliations

Soon will be listed here.

Abstract

Background: The rate of revision for some designs of total hip replacements due to idiopathic aseptic loosening has been reported as higher for women. However, whether this is environmental or inherently sex-related is not clear.

Objective: Can particle induced osteolysis be sex dependent? And if so, is this dependent on the type of implant debris (. metal polymer)? The objective of this study was to test for material dependent inflammatory osteolysis that may be linked to sex using CoCrMo and implant grade conventional polyethylene (UHMWPE), using an murine calvaria model.

Methods: Healthy 12 week old female and male C57BL/6J mice were treated with UHMWPE (1.0um ECD) or CoCrMo particles (0.9um ECD) or received sham surgery. Bone resorption was assessed by micro-computed tomography, histology and histomorphometry on day 12 post challenge.

Results: Female mice that received CoCrMo particles showed significantly more inflammatory osteolysis and bone destruction compared to the females who received UHMWPE implant debris. Moreover, females challenged with CoCrMo particles exhibited 120% more inflammatory bone loss compared to males (p<0.01) challenged with CoCrMo implant debris (but this was not the case for UHMWPE particles).

Conclusion: We demonstrated sex-specific differences in the amount of osteolysis resulting from CoCrMo particle challenge. This suggests osteo-immune responses to metal debris are preferentially higher in female compared to male mice, and supports the contention that there may be inherent sex related susceptibility to some types of implant debris.

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