The Role of the Oncogenic Rab35 in Cancer Invasion, Metastasis, and Immune Evasion, Especially in Leukemia

Overview

Journal Small GTPases

Specialties Biochemistry
Cell Biology

Date 2018 May 22

PMID 29781368

Citations 14

Authors

Fabian R Villagomez

Oscar Medina-Contreras

Jorge Francisco Cerna-Cortes

Genaro Patino-Lopez

Affiliations

Soon will be listed here.

Abstract

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia.

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