Neutrophils in Traumatic Brain Injury (TBI): Friend or Foe?

Overview

Journal J Neuroinflammation

Publisher Biomed Central

Date 2018 May 20

PMID 29776443

Citations 68

Authors

Yang-Wuyue Liu

Song Li

Shuang-Shuang Dai

Affiliations

Soon will be listed here.

Abstract

Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.

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