Cytotoxic and Other Withanolides from Aeroponically Grown Physalis Philadelphica

Overview

Journal Phytochemistry

Publisher Elsevier

Specialties Biochemistry
Biology
Chemistry

Date 2018 May 19

PMID 29775868

Citations 14

Authors

Ya-Ming Xu

E M Kithsiri Wijeratne

Alan D Brooks

Poonam Tewary

Li-Jiang Xuan

Wen-Qiong Wang

Thomas J Sayers

A A Leslie Gunatilaka

Affiliations

Soon will be listed here.

Abstract

Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.

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