Could Autism Be Associated With Nutritional Status in the Palestinian Population? The Outcomes of the Palestinian Micronutrient Survey

Overview

Journal Nutr Metab Insights

Publisher Sage Publications

Specialty Endocrinology

Date 2018 May 19

PMID 29773950

Citations 5

Authors

Mohammad Altamimi

Affiliations

Soon will be listed here.

Abstract

Background: Autism spectrum disorder is a neurodevelopmental disorder. It is believed that the cause of autism is multifactorial, where genetic predispositions interact with environmental factors. In this context, micronutrients play a crucial role.

Objective: To present evidence on current micronutrient status in Palestine and highlight its possible role in increasing problems of neurodevelopment disorders in general and autism in particular.

Method: Analytical review of results.

Results And Conclusions: The Palestinian Micronutrient Survey was conducted to assess micronutrient status in most vulnerable groups and also micronutrient deficiencies. The data from Palestinian population showed severe anaemia due to iron, Zn, B12, and folic acid deficiencies. One in every 3 Palestinian pregnant women is anaemic. Moreover, 78.2% and 87.1% of lactating mothers from the West Bank and Gaza Strip are Zn deficient. For children from 6 to 59 months old, 1 in every 4 boys and 1 in every 5 girls are considered anaemic. Similar trend was found with respect to vitamins E, D, A, and folic acid. We reviewed the literature that linked micronutrient deficiencies to neurodevelopmental disorders and expected the number of neurodevelopmental disorder cases, including autism, to increase.

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References

Neggers Y . The Relationship between Folic Acid and Risk of Autism Spectrum Disorders. Healthcare (Basel). 2016; 2(4):429-44. PMC: 4934568. DOI: 10.3390/healthcare2040429. View

. CDC Grand Rounds: additional opportunities to prevent neural tube defects with folic acid fortification. MMWR Morb Mortal Wkly Rep. 2010; 59(31):980-4. View

Suren P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D . Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA. 2013; 309(6):570-7. PMC: 3908544. DOI: 10.1001/jama.2012.155925. View

Holick M . High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006; 81(3):353-73. DOI: 10.4065/81.3.353. View

Surkan P, Siegel E, Patel S, Katz J, Khatry S, Stoltzfus R . Effects of zinc and iron supplementation fail to improve motor and language milestone scores of infants and toddlers. Nutrition. 2013; 29(3):542-8. PMC: 3761420. DOI: 10.1016/j.nut.2012.09.003. View

Black M . The evidence linking zinc deficiency with children's cognitive and motor functioning. J Nutr. 2003; 133(5 Suppl 1):1473S-6S. PMC: 3137935. DOI: 10.1093/jn/133.5.1473S. View

Hodgson N, Waly M, Al-Farsi Y, Al-Sharbati M, Al-Farsi O, Ali A . Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman. Exp Biol Med (Maywood). 2014; 239(6):697-706. DOI: 10.1177/1535370214527900. View

Neggers Y . Increasing prevalence, changes in diagnostic criteria, and nutritional risk factors for autism spectrum disorders. ISRN Nutr. 2014; 2014:514026. PMC: 4045304. DOI: 10.1155/2014/514026. View

Schmidt R, Tancredi D, Ozonoff S, Hansen R, Hartiala J, Allayee H . Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr. 2012; 96(1):80-9. PMC: 3374734. DOI: 10.3945/ajcn.110.004416. View

10.

Strauss M . ANEMIA OF INFANCY FROM MATERNAL IRON DEFICIENCY IN PREGNANCY. J Clin Invest. 1933; 12(2):345-53. PMC: 435912. DOI: 10.1172/JCI100507. View

11.

Ghanizadeh A, Akhondzadeh S, Hormozi M, Makarem A, Abotorabi-Zarchi M, Firoozabadi A . Glutathione-related factors and oxidative stress in autism, a review. Curr Med Chem. 2012; 19(23):4000-5. DOI: 10.2174/092986712802002572. View

12.

Schmidt R, Tancredi D, Krakowiak P, Hansen R, Ozonoff S . Maternal intake of supplemental iron and risk of autism spectrum disorder. Am J Epidemiol. 2014; 180(9):890-900. PMC: 4207718. DOI: 10.1093/aje/kwu208. View

13.

Beard C, Panser L, Katusic S . Is excess folic acid supplementation a risk factor for autism?. Med Hypotheses. 2011; 77(1):15-7. DOI: 10.1016/j.mehy.2011.03.013. View

14.

Castro K, Klein L, Baronio D, Gottfried C, Riesgo R, Perry I . Folic acid and autism: What do we know?. Nutr Neurosci. 2014; 19(7):310-7. DOI: 10.1179/1476830514Y.0000000142. View

15.

Steenweg-de Graaff J, Roza S, Steegers E, Hofman A, Verhulst F, Jaddoe V . Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study. Am J Clin Nutr. 2012; 95(6):1413-21. DOI: 10.3945/ajcn.111.030791. View

16.

Saad K, Abdel-Rahman A, Elserogy Y, Al-Atram A, Cannell J, Bjorklund G . Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutr Neurosci. 2015; 19(8):346-351. DOI: 10.1179/1476830515Y.0000000019. View

17.

Kaur M, Chauhan A, Manzar M, Rajput M . Maternal Anaemia and Neonatal Outcome: A Prospective Study on Urban Pregnant Women. J Clin Diagn Res. 2016; 9(12):QC04-8. PMC: 4717682. DOI: 10.7860/JCDR/2015/14924.6985. View

18.

Tseng P, Cheng Y, Chen Y, Stubbs B, Whiteley P, Carvalho A . Peripheral iron levels in children with autism spectrum disorders vs controls: a systematic review and meta-analysis. Nutr Res. 2018; 50:44-52. DOI: 10.1016/j.nutres.2017.11.004. View

19.

Roth C, Magnus P, Schjolberg S, Stoltenberg C, Suren P, McKeague I . Folic acid supplements in pregnancy and severe language delay in children. JAMA. 2011; 306(14):1566-73. PMC: 3780384. DOI: 10.1001/jama.2011.1433. View

20.

Ali Y, Anderson L, Smile S, Chen Y, Borkhoff C, Koroshegyi C . Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood. Autism. 2024; 23(3):584-593. DOI: 10.1177/1362361318756787. View