Association Between Different Combination of Measures for Obesity and New-onset Gallstone Disease

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 May 18

PMID 29772027

Citations 15

Authors

Tong Liu

Wanchao Wang

Yannan Ji

Yiming Wang

Xining Liu

Liying Cao

Siqing Liu

Affiliations

Soon will be listed here.

Abstract

Background: Body mass index(BMI) is a calculation index of general obesity. Waist circumference(WC) is a measure of body-fat distribution and always used to estimate abdominal obesity. An important trait of general obesity and abdominal obesity is their propensity to coexist. Using one single measure of obesity could not estimate persons at risk for GSD precisely.

Objectives: This study aimed to compare the predictive values of various combination of measures for obesity(BMI, WC, waist to hip ratio) for new-onset GSD.

Methods: We prospectively studied the predictive values of various combination of measures for obesity for new-onset GSD in a cohort of 88,947 participants who were free of prior gallstone disease, demographic characteristics and biochemical parameters were recorded.

Results: 4,329 participants were identified to have GSD among 88,947 participants during 713 345 person-years of follow-up. Higher BMI, WC and waist to hip ratio (WHtR) were significantly associated with higher risks of GSD in both genders even after adjustment for potential confounders. In males, the hazard ratio for the highest versus lowest BMI, WC, WHtR were 1.63(1.47~1.79), 1.53(1.40~1.68), 1.44(1.31~1.58), respectively. In females, the hazard ratio for the highest versus lowest BMI, WC, WHtR were 2.11(1.79~2.49), 1.85(1.55~2.22), 1.84(1.55~2.19), respectively. In male group, the combination of BMI+WC improved the predictive ability of the model more clearly than other combinations after adding them to the multivariate model in turn, while for females the best predictive combination was BMI+WHtR.

Conclusions: Elevated BMI, WC and WHtR were independent risk factors for new-onset GSD in both sex groups after additional adjustment was made for potential confounders. In males, the combination of BMI+WC seemed to be the most predictable model to evaluate the effect of obesity on new-onset GSD, while the best combination in females was BMI+WHtR.

Citing Articles

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Comparison of Triglyceride-Glucose Index between Patients with Gallstone and Healthy Individuals.

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Sex disparities in gallstone disease: insights from the MAUCO prospective population-based cohort study.

Rodriguez Gatta D, Huidobro L, Petermann-Rocha F, Van de Wyngard V, Godoy F, Cid V BMJ Open Gastroenterol. 2024; 11(1).

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Associations between novel anthropometric indices and the prevalence of gallstones among 6,848 adults: a cross-sectional study.

Zhang J, Liang D, Xu L, Liu Y, Jiang S, Han X Front Nutr. 2024; 11:1428488.

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