Gestational Trophoblastic Neoplasia After Ectopic Molar Pregnancy: Clinical, Diagnostic, and Therapeutic Aspects

Overview

Journal Rev Bras Ginecol Obstet

Specialty Gynecology & Obstetrics

Date 2018 May 17

PMID 29768638

Citations 6

Authors

Consuelo Lozoya Lopez

Vania Gloria Silami Lopes

Fabiana Rodrigues Resende

Jessica Lara Steim

Lilian Padron

Sue Yazaki Sun

Edward Araujo Junior

Antonio Braga

Affiliations

Soon will be listed here.

Abstract

This report presents the case of a patient with gestational trophoblastic neoplasia after a partial hydatidiform mole formed in the Fallopian tube. Ectopic molar pregnancy is a rare condition, with an estimated incidence of 1 in every 20,000 to 100,000 pregnancies; less than 300 cases of it have been reported in the Western literature. The present report is important because it presents current diagnostic criteria for this rare condition, which has been incorrectly diagnosed in the past, not only morphologically but also immunohistochemically. It also draws the attention of obstetricians to the occurrence of ectopic molar pregnancy, which tends to progress to Fallopian tube rupture more often than in cases of ectopic non-molar pregnancy. Progression to gestational trophoblastic neoplasia ensures that patients with ectopic molar pregnancy must undergo postmolar monitoring, which must be just as thorough as that of patients with intrauterine hydatidiform moles, even if chemotherapy results in high cure rates.

Citing Articles

Cornual invasive hydatidiform mole: a rare case report and literature review.

Qian J, Xu S, Chen L BMC Womens Health. 2023; 23(1):566.

PMID: 37919704 PMC: 10621079. DOI: 10.1186/s12905-023-02727-z.

A rare case of ectopic partial molar pregnancy following IVF.

Hosseini S, Hajizadeh N, Ghotbi E, Esmi M JBRA Assist Reprod. 2023; .

PMID: 37579273 PMC: 10718537. DOI: 10.5935/1518-0557.20230030.

Ruptured ectopic molar pregnancy and ruptured uterine fibroid: a challenging rare diagnosis.

Tanudisastro M, Chatterjee R, Anderson L, Smirnova S BMJ Case Rep. 2023; 16(1.

PMID: 36653040 PMC: 9853148. DOI: 10.1136/bcr-2022-251045.

Is It Possible to Diagnose Preoperatively a Tubal Ectopic Hydatidiform Molar Pregnancy? Description of a Case Report and Review of the Literature of the Last Ten Years.

DAsta M, La Ferrera N, Gulino F, Ettore C, Ettore G J Clin Med. 2022; 11(19).

PMID: 36233651 PMC: 9572751. DOI: 10.3390/jcm11195783.

A rare case of gestational trophoblastic neoplasia following an ectopic molar pregnancy.

Dollinger S, Yeoshoua E, Eitan R Gynecol Oncol Rep. 2021; 37:100798.

PMID: 34159242 PMC: 8193366. DOI: 10.1016/j.gore.2021.100798.

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