Fine Particulate Matter Associated Mortality Burden of Lung Cancer in Hebei Province, China

Overview

Journal Thorac Cancer

Specialties Oncology
Pulmonary Medicine

Date 2018 May 15

PMID 29756316

Citations 5

Authors

Yutong He

Zhaoyu Gao

Tiantian Guo

Feng Qu

Di Liang

Daojuan Li

Jin Shi

Baoen Shan

Affiliations

Soon will be listed here.

Abstract

Background: The association between fine particulate matter (PM ) and lung cancer (LC) mortality in China is limited. The Beijing-Tianjin-Hebei region is infamous for serious air pollution. Seven of the top 10 cities with the worst air quality are located in Hebei Province. Thus, we explored the effect of 10 years of PM on the LC mortality rate in Hebei Province.

Methods: We quantified associations between LC mortality and PM and estimated the LC mortality burden attributed to PM with predicted county level LC deaths in 2014.

Results: The 10-year PM LC mortality associations were non-linear, with thresholds of 63 μg/m overall, 69 μg/m for men, 68 μg/m for women, 66 μg/m for those aged 30-64 years, and 62 μg/m for those aged ≥ 65 years. The relative risks for these groups were 1.09 (95% confidence interval [CI] 1.08-1.10), 1.06 (95% CI 1.03-1.10), 1.20 (95% CI 1.10-1.26), 1.07 (95% CI 1.05-1.11), and 1.10 (95% CI: 1.07-1.13), respectively. There were 2525 (95% CI 2265-2780) LC deaths attributed to 10-year PM in 2014, at fractions of 8.3% (95% CI 7.4-9.1%) overall, 5.7% (95% CI 2.8-9.4%) for men, 16.7% (95% CI: 8.3-21.6%) for women, 6.5% (95% CI 4.7-10.3%) for those aged 30-64 years, and 9.1% (95% CI 6.4-11.5%) for those aged ≥ 65 years.

Conclusion: Our results suggest that a reduction in the PM exposure levels below thresholds would prevent a substantial number of LC deaths in Hebei Province.

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References

Huang F, Pan B, Wu J, Chen E, Chen L . Relationship between exposure to PM2.5 and lung cancer incidence and mortality: A meta-analysis. Oncotarget. 2017; 8(26):43322-43331. PMC: 5522148. DOI: 10.18632/oncotarget.17313. View

Lin H, Ma W, Qiu H, Wang X, Trevathan E, Yao Z . Using daily excessive concentration hours to explore the short-term mortality effects of ambient PM in Hong Kong. Environ Pollut. 2017; 229:896-901. DOI: 10.1016/j.envpol.2017.07.060. View

Yin Z, Cui Z, Ren Y, Zhang H, Yan Y, Zhao Y . Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case-control study in a Chinese non-smoking female population. Med Oncol. 2014; 31(8):114. DOI: 10.1007/s12032-014-0114-5. View

van Donkelaar A, Martin R, Brauer M, Boys B . Use of satellite observations for long-term exposure assessment of global concentrations of fine particulate matter. Environ Health Perspect. 2014; 123(2):135-43. PMC: 4314252. DOI: 10.1289/ehp.1408646. View

Villeneuve P, Weichenthal S, Crouse D, Miller A, To T, Martin R . Long-term Exposure to Fine Particulate Matter Air Pollution and Mortality Among Canadian Women. Epidemiology. 2015; 26(4):536-45. DOI: 10.1097/EDE.0000000000000294. View

He Q, Geng F, Li C, Yang S, Wang Y, Mu H . Long-term characteristics of satellite-based PM over East China. Sci Total Environ. 2017; 612:1417-1423. DOI: 10.1016/j.scitotenv.2017.09.027. View

. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1659-1724. PMC: 5388856. DOI: 10.1016/S0140-6736(16)31679-8. View

Zhang H, Wang Z, Zhang W . Exploring spatiotemporal patterns of PM2.5 in China based on ground-level observations for 190 cities. Environ Pollut. 2016; 216:559-567. DOI: 10.1016/j.envpol.2016.06.009. View

van Donkelaar A, Martin R, Brauer M, Hsu N, Kahn R, Levy R . Global Estimates of Fine Particulate Matter using a Combined Geophysical-Statistical Method with Information from Satellites, Models, and Monitors. Environ Sci Technol. 2016; 50(7):3762-72. DOI: 10.1021/acs.est.5b05833. View

10.

Chen W, Zheng R, Zhang S, Zeng H, Xia C, Zuo T . Cancer incidence and mortality in China, 2013. Cancer Lett. 2017; 401:63-71. DOI: 10.1016/j.canlet.2017.04.024. View

11.

Cohen A, Brauer M, Burnett R, Anderson H, Frostad J, Estep K . Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015. Lancet. 2017; 389(10082):1907-1918. PMC: 5439030. DOI: 10.1016/S0140-6736(17)30505-6. View

12.

He Y, Liang D, Li D, Shi J, Jin J, Zhai J . Cancer incidence and mortality in Hebei province, 2013. Medicine (Baltimore). 2017; 96(26):e7293. PMC: 5500051. DOI: 10.1097/MD.0000000000007293. View

13.

Beelen R, Raaschou-Nielsen O, Stafoggia M, Andersen Z, Weinmayr G, Hoffmann B . Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet. 2013; 383(9919):785-95. DOI: 10.1016/S0140-6736(13)62158-3. View

14.

Kan H, London S, Chen G, Zhang Y, Song G, Zhao N . Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China. Environ Int. 2007; 33(3):376-84. PMC: 2094002. DOI: 10.1016/j.envint.2006.12.001. View

15.

Hall E, Hei T . Genomic instability and bystander effects induced by high-LET radiation. Oncogene. 2003; 22(45):7034-42. DOI: 10.1038/sj.onc.1206900. View

16.

Yang C, Peng X, Huang W, Chen R, Xu Z, Chen B . A time-stratified case-crossover study of fine particulate matter air pollution and mortality in Guangzhou, China. Int Arch Occup Environ Health. 2011; 85(5):579-85. DOI: 10.1007/s00420-011-0707-7. View

17.

Yang W, Zhao H, Wang X, Deng Q, Fan W, Wang L . An evidence-based assessment for the association between long-term exposure to outdoor air pollution and the risk of lung cancer. Eur J Cancer Prev. 2015; 25(3):163-72. DOI: 10.1097/CEJ.0000000000000158. View

18.

Turner M, Jerrett M, Pope 3rd C, Krewski D, Gapstur S, Diver W . Long-Term Ozone Exposure and Mortality in a Large Prospective Study. Am J Respir Crit Care Med. 2015; 193(10):1134-42. PMC: 4872664. DOI: 10.1164/rccm.201508-1633OC. View

19.

Feng L, Ye B, Feng H, Ren F, Huang S, Zhang X . Spatiotemporal Changes in Fine Particulate Matter Pollution and the Associated Mortality Burden in China between 2015 and 2016. Int J Environ Res Public Health. 2017; 14(11). PMC: 5707960. DOI: 10.3390/ijerph14111321. View

20.

Islami F, Chen W, Yu X, Lortet-Tieulent J, Zheng R, Flanders W . Cancer deaths and cases attributable to lifestyle factors and infections in China, 2013. Ann Oncol. 2017; 28(10):2567-2574. DOI: 10.1093/annonc/mdx342. View