Aging Increases Susceptibility to Ovarian Cancer Metastasis in Murine Allograft Models and Alters Immune Composition of Peritoneal Adipose Tissue

Overview

Journal Neoplasia

Publisher Elsevier

Specialty Oncology

Date 2018 May 14

PMID 29754071

Citations 17

Authors

Elizabeth A Loughran

Annemarie K Leonard

Tyvette S Hilliard

Ryan C Phan

Madeleine G Yemc

Elizabeth Harper

Emma Sheedy

Yuliya Klymenko

Marwa Asem

Yueying Liu

Jing Yang

Jeff Johnson

Laura Tarwater

Zonggao Shi

Matthew Leevy

Matthew J Ravosa

M Sharon Stack

Affiliations

Soon will be listed here.

Abstract

Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis. Here we report that the aged host is more susceptible to metastatic success using two murine syngeneic allograft models of ovarian cancer metastasis. This age-related increase in metastatic tumor burden corresponds with an increase in tumor infiltrating lymphocytes (TILs) in tumor-bearing mice and alteration of B cell-related pathways in gonadal adipose tissue. Based on this work, further studies elucidating the status of B cell TILs in mouse models of metastasis and human tumors in the context of aging are warranted.

Citing Articles

Regulation of Age-Related Lipid Metabolism in Ovarian Cancer.

Feng J, Rouse C, Taylor L, Garcia S, Nguyen E, Coogan I Int J Mol Sci. 2025; 26(1.

PMID: 39796176 PMC: 11720209. DOI: 10.3390/ijms26010320.

Gender- and Age-Based Characterization and Comparison of the Murine Primary Peritoneal Mesothelial Cell Proteome.

Wang Z, Liu Y, Safavisohi R, Asem M, Hu D, Stack M bioRxiv. 2024; .

PMID: 39416176 PMC: 11482775. DOI: 10.1101/2024.10.09.617441.

Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study.

Fujimoto H, Yoshihara M, Ricciardelli C, Tano S, Iyoshi S, Miyamoto E Sci Rep. 2024; 14(1):23537.

PMID: 39384823 PMC: 11479624. DOI: 10.1038/s41598-024-66419-w.

Combination non-targeted and sGRP78-targeted nanoparticle drug delivery outperforms either component to treat metastatic ovarian cancer.

Sjoerdsma J, Bromley E, Shin J, Hilliard T, Liu Y, Horgan C J Control Release. 2024; 375:438-453.

PMID: 39271060 PMC: 11486564. DOI: 10.1016/j.jconrel.2024.09.014.

Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy.

Liu Y, Yang J, Hilliard T, Wang Z, Johnson J, Wang W J Exp Clin Cancer Res. 2023; 42(1):165.

PMID: 37438818 PMC: 10337170. DOI: 10.1186/s13046-023-02740-y.

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