Salivary Sex Hormones in Adolescent Females with Trichotillomania

Overview

Journal Psychiatry Res

Specialty Psychiatry

Date 2018 May 13

PMID 29753253

Citations 2

Authors

Jon E Grant

Samuel R Chamberlain

Affiliations

Soon will be listed here.

Abstract

Trichotillomania is several times more common in women and has peak onset around puberty. The role of sex hormones, however, has received little research. 11 adolescent girls with trichotillomania, post-menarche and not taking birth control, were examined on a variety of clinical measures. Participants provided saliva samples for analysis of estradiol, progesterone, and testosterone levels. Lower progesterone was associated with more severe symptoms and lower levels of all hormones were associated with worse overall functioning. Adolescents with trichotillomania exhibit a range of hormone levels but that lower levels of certain hormones may have important clinical associations.

Citing Articles

Estradiol and Women's Health: Considering the Role of Estradiol as a Marker in Behavioral Medicine.

Rieder J, Darabos K, Weierich M Int J Behav Med. 2020; 27(3):294-304.

PMID: 32006161 DOI: 10.1007/s12529-019-09820-4.

Trichotillomania (hair pulling disorder).

Grant J Indian J Psychiatry. 2019; 61(Suppl 1):S136-S139.

PMID: 30745687 PMC: 6343418. DOI: 10.4103/psychiatry.IndianJPsychiatry_529_18.

References

Szepietowski J, Salomon J, Pacan P, Hrehorow E, Zalewska A . Frequency and treatment of trichotillomania in Poland. Acta Derm Venereol. 2009; 89(3):267-70. DOI: 10.2340/00015555-0630. View

Op de Macks Z, Gunther Moor B, Overgaauw S, Guroglu B, Dahl R, Crone E . Testosterone levels correspond with increased ventral striatum activation in response to monetary rewards in adolescents. Dev Cogn Neurosci. 2012; 1(4):506-16. PMC: 6987540. DOI: 10.1016/j.dcn.2011.06.003. View

Wirth M . Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and Emotion. Front Endocrinol (Lausanne). 2012; 2:19. PMC: 3355912. DOI: 10.3389/fendo.2011.00019. View

Cohen L, Stein D, Simeon D, Spadaccini E, Rosen J, Aronowitz B . Clinical profile, comorbidity, and treatment history in 123 hair pullers: a survey study. J Clin Psychiatry. 1995; 56(7):319-26. View

Dillon K, Brooks D . Unusual cleaning behavior in the luteal phase. Psychol Rep. 1992; 70(1):35-9. DOI: 10.2466/pr0.1992.70.1.35. View

Flaisher-Grinberg S, Albelda N, Gitter L, Weltman K, Arad M, Joel D . Ovarian hormones modulate 'compulsive' lever-pressing in female rats. Horm Behav. 2008; 55(2):356-65. DOI: 10.1016/j.yhbeh.2008.10.002. View

Christenson G, Mackenzie T, Mitchell J . Characteristics of 60 adult chronic hair pullers. Am J Psychiatry. 1991; 148(3):365-70. DOI: 10.1176/ajp.148.3.365. View

Neziroglu F, Anemone R, Yaryura-Tobias J . Onset of obsessive-compulsive disorder in pregnancy. Am J Psychiatry. 1992; 149(7):947-50. DOI: 10.1176/ajp.149.7.947. View

Grant J, Chamberlain S . Trichotillomania. Am J Psychiatry. 2016; 173(9):868-74. PMC: 5328413. DOI: 10.1176/appi.ajp.2016.15111432. View

10.

dAngelo L, Eagle D, Grant J, Fineberg N, Robbins T, Chamberlain S . Animal models of obsessive-compulsive spectrum disorders. CNS Spectr. 2013; 19(1):28-49. DOI: 10.1017/S1092852913000564. View

11.

Wirth M, Meier E, Fredrickson B, Schultheiss O . Relationship between salivary cortisol and progesterone levels in humans. Biol Psychol. 2006; 74(1):104-7. DOI: 10.1016/j.biopsycho.2006.06.007. View

12.

Swedo S, Leonard H, Rapoport J, Lenane M, Goldberger E, Cheslow D . A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling). N Engl J Med. 1989; 321(8):497-501. DOI: 10.1056/NEJM198908243210803. View

13.

Mitra S, Bastos C, Bates K, Pereira G, Bult-Ito A . Ovarian Sex Hormones Modulate Compulsive, Affective and Cognitive Functions in A Non-Induced Mouse Model of Obsessive-Compulsive Disorder. Front Behav Neurosci. 2016; 10:215. PMC: 5101197. DOI: 10.3389/fnbeh.2016.00215. View

14.

Grant J, Redden S, Leppink E, Chamberlain S, Curley E, Tung E . Sex differences in trichotillomania. Ann Clin Psychiatry. 2016; 28(2):118-24. View

15.

Keuthen N, OSullivan R, Hayday C, Peets K, Jenike M, Baer L . The relationship of menstrual cycle and pregnancy to compulsive hairpulling. Psychother Psychosom. 1997; 66(1):33-7. DOI: 10.1159/000289103. View

16.

Keuthen N, OSullivan R, Ricciardi J, Shera D, Savage C, Borgmann A . The Massachusetts General Hospital (MGH) Hairpulling Scale: 1. development and factor analyses. Psychother Psychosom. 1995; 64(3-4):141-5. DOI: 10.1159/000289003. View

17.

Traber J, Spencer Jr D, Glaser T, Gispen W . Actions of psychoactive drugs on ACTH- and novelty-induced behavior in the rat. Ann N Y Acad Sci. 1988; 525:270-80. DOI: 10.1111/j.1749-6632.1988.tb38612.x. View

18.

Schwabe M, Konkol R . Menstrual cycle-related fluctuations of tics in Tourette syndrome. Pediatr Neurol. 1992; 8(1):43-6. DOI: 10.1016/0887-8994(92)90051-y. View

19.

Childs E, Dlugos A, de Wit H . Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase. Psychophysiology. 2010; 47(3):550-9. PMC: 4242596. DOI: 10.1111/j.1469-8986.2009.00961.x. View

20.

Fernandez-Guasti A, Agrati D, Reyes R, Ferreira A . Ovarian steroids counteract serotonergic drugs actions in an animal model of obsessive-compulsive disorder. Psychoneuroendocrinology. 2006; 31(8):924-34. DOI: 10.1016/j.psyneuen.2006.05.003. View