A Systematic Review and Meta-analysis of the Prevalence of Toxoplasmosis in Hemodialysis Patients in Iran

Overview

Journal Epidemiol Health

Specialty Public Health

Date 2018 May 12

PMID 29748456

Citations 24

Authors

Masoud Foroutan

Ali Rostami

Hamidreza Majidiani

Seyed Mohammad Riahi

Sasan Khazaei

Milad Badri

Elham Yousefi

Affiliations

Soon will be listed here.

Abstract

Objectives: Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of among patients undergoing hemodialysis in Iran.

Methods: We searched English and Persian databases for studies reporting seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.

Results: A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against infection than healthy individuals.

Conclusions: The current study revealed a high prevalence of infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and can cause serious clinical complications, we recommend that periodic screenings for infection should be incorporated into the routine clinical care of these patients.

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