[Research Progress of Neurobiological Function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline]

Overview

Journal Sheng Wu Yi Xue Gong Cheng Xue Za Zhi

Specialty Biomedical Engineering

Date 2018 May 11

PMID 29745566

Authors

Xiaotong Zheng

Xuechai Chen

Zixuan Chen

Hong Qing

Yulin Deng

Rugang Zhong

Minjun Guo

Affiliations

Soon will be listed here.

Abstract

1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (Sal) is a kind of catechol isoquinoline compound, which mainly exists in mammalian brain and performs a variety of biological functions. Through metabolism, Sal can be transformed into endogenous neurotoxins and can participate the occurrence of Parkinson's disease (PD). This has attracted widespread concern of researchers. Recently, many research works have shown that Sal may lead to alcohol addiction and regulate hormone release of the neuroendocrine system, which indicated that it is a potential regulator of dopaminergic neurons. In this paper, we discuss the neural functions of Sal on the above aspects, and wish to provide some theoretical supports for further research on its mechanism.

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