Identical Anthropometric Characteristics of Impaired Fasting Glucose Combined with Impaired Glucose Tolerance and Newly Diagnosed Type 2 Diabetes: Anthropometric Indicators to Predict Hyperglycaemia in a Community-based Prospective Cohort Study In...

Overview

Journal BMJ Open

Specialty General Medicine

Date 2018 May 11

PMID 29743321

Citations 10

Authors

Fang Zhang

Qin Wan

Hongyi Cao

Lizhi Tang

Daigang Li

Qingguo Lu

Zhe Yan

Jing Li

Qiu Yang

Yuwei Zhang

Nanwei Tong

Affiliations

Soon will be listed here.

Abstract

Objectives: To assess the anthropometric characteristics of normoglycaemic individuals who subsequently developed hyperglycaemia, and to evaluate the validity of these measures to predict prediabetes and diabetes.

Design: A community-based prospective cohort study.

Participants: In total, 1885 residents with euglycaemia at baseline from six communities were enrolled.

Setting: Sichuan, southwest China.

Primary Outcome Measures: The incidences of prediabetes and diabetes were the primary outcomes.

Methods: The waist-to-height ratio (WHtR), body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) of all participants were measured at baseline and during follow-up. A 75 g glucose oral glucose tolerance test was conducted at each survey.

Results: During a median of 3.00 (IQR: 2.92-4.17) years follow-up, the cumulative incidence of isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), IFG combined with IGT (IFG+IGT), and newly diagnosed diabetes mellitus (NDDM) were 8.44%, 18.14%, 8.06% and 13.79%, respectively. WHtR, BMI, WC and WHR were significantly different among subjects who subsequently progressed to isolated IFG or IGT, IFG+IGT or NDDM (p<0.05). The anthropometric characteristics of IFG+IGT subjects were similar to those of the NDDM population (p>0.005). All the baseline anthropometric measurements were useful for the prediction of future prediabetes and NDDM (p<0.05). The optimal thresholds for the four measurements were calculated for the prediction of hyperglycaemia, with a WHtR value of 0.52 performing best to identify isolated IFG or IGT, IFG+IGT and NDDM.

Conclusions: Anthropometric measures, especially WHtR, could be used to predict hyperglycaemia 3 years in advance. Distinct from isolated IFG and IGT, the individuals who developed combined IFG+IGT had identical anthropometric profiles to those who progressed to NDDM.

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