Nanosized Titanium Dioxide-induced Premature Ovarian Failure is Associated with Abnormalities in Serum Parameters in Female Mice

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2018 May 8

PMID 29731629

Citations 16

Authors

Fashui Hong

Ling Wang

Affiliations

Soon will be listed here.

Abstract

Background: Exposure to titanium dioxide nanoparticles (TiO NPs) that are widely used in food, medicine, sunscreen products and cosmetics is reported to cause ovarian damage and lower fertility in animals. However, the potential effects of TiO NPs application on premature ovarian failure (POF) have rarely been evaluated to date.

Methods: In this study, female mice were continuously exposed to TiO NPs at doses of 2.5, 5 or 10 mg/kg via gavage instillation for 30 days, and investigated the serum hormones and autoimmunity markers associated with POF.

Results: Exposure to TiO NPs resulted in POF, reductions in the levels of estradiol, progesterone and inhibin B and increases in luteinizing hormone, follicle-stimulating hormone, follicle-stimulating hormone/luteinizing hormone ratio, anti-Müllerian hormone, thyroid-stimulating hormone, free triiodothyronine, free tetraiodothyronine, anti-nuclear antibody and anti-thyroid peroxidase antibody levels in serum.

Conclusion: Exposure to TiO NPs induced POF triggered by alterations in hormones and autoimmunity markers. Our findings highlight the necessity for significant caution in handling and usage of TiO NPs by female consumers.

Citing Articles

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Titanium dioxide nanoparticles Disrupt ultrastructure and function of Rat thyroid tissue via oxidative stress.

Gong H, Li S, Wang F, Zhu Y, Jiang Q, Zhu X Heliyon. 2024; 10(14):e34722.

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Titanium Dioxide Nanoparticles Induce Maternal Preeclampsia-like Syndrome and Adverse Birth Outcomes via Disrupting Placental Function in SD Rats.

Li H, Miao D, Hu H, Xue P, Zhou K, Mao Z Toxics. 2024; 12(5).

PMID: 38787146 PMC: 11125676. DOI: 10.3390/toxics12050367.

TiC nanosheet-induced autophagy derails ovarian functions.

Yang L, He Z, Hu L, Tang H, Geng Y, Tan Q J Nanobiotechnology. 2024; 22(1):242.

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Fructose improves titanium dioxide nanoparticles induced alterations in developmental competence of mouse oocytes.

Elmetwally M, Helmy A, Balboula A, Eladl M, Hamed B, Lashen S BMC Vet Res. 2024; 20(1):135.

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References

Revelli A, Casano S, Delle Piane L, Grassi G, Gennarelli G, Guidetti D . A retrospective study on IVF outcome in euthyroid patients with anti-thyroid antibodies: effects of levothyroxine, acetyl-salicylic acid and prednisolone adjuvant treatments. Reprod Biol Endocrinol. 2009; 7:137. PMC: 2788572. DOI: 10.1186/1477-7827-7-137. View

Kreyling W, Holzwarth U, Haberl N, Kozempel J, Wenk A, Hirn S . Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3. Nanotoxicology. 2017; 11(4):454-464. DOI: 10.1080/17435390.2017.1306894. View

Prummel M, Wiersinga W . Thyroid peroxidase autoantibodies in euthyroid subjects. Best Pract Res Clin Endocrinol Metab. 2005; 19(1):1-15. DOI: 10.1016/j.beem.2004.11.003. View

Cramer D, Sluss P, Powers R, McShane P, Ginsburgs E, Hornstein M . Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function?. J Assist Reprod Genet. 2003; 20(6):210-5. PMC: 3455321. DOI: 10.1023/a:1024151210536. View

Wu C, Chen Y, Wu H, Yang J, Chang Y, Tsai H . Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients. J Assist Reprod Genet. 2009; 26(7):383-9. PMC: 2758947. DOI: 10.1007/s10815-009-9332-8. View

Stagnaro-Green A, Roman S, Cobin R, Davies T . Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. JAMA. 1990; 264(11):1422-5. View

Zhao X, Ze Y, Gao G, Sang X, Li B, Gui S . Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice. PLoS One. 2013; 8(4):e59378. PMC: 3615008. DOI: 10.1371/journal.pone.0059378. View

Kreyling W, Holzwarth U, Schleh C, Kozempel J, Wenk A, Haberl N . Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2. Nanotoxicology. 2017; 11(4):443-453. DOI: 10.1080/17435390.2017.1306893. View

Srouji S, Mark A, Levine Z, Betensky R, D Hornstein M, Ginsburg E . Predicting in vitro fertilization live birth using stimulation day 6 estradiol, age, and follicle-stimulating hormone. Fertil Steril. 2005; 84(3):795-7. DOI: 10.1016/j.fertnstert.2005.02.042. View

10.

Broekmans F, Soules M, Fauser B . Ovarian aging: mechanisms and clinical consequences. Endocr Rev. 2009; 30(5):465-93. DOI: 10.1210/er.2009-0006. View

11.

Arojoki M, Jokimaa V, Juuti A, Koskinen P, Irjala K, Anttila L . Hypothyroidism among infertile women in Finland. Gynecol Endocrinol. 2000; 14(2):127-31. DOI: 10.3109/09513590009167671. View

12.

Sundarrajan C, Liao W, Roy A, Ng S . Association between estrogen receptor-beta gene polymorphisms and ovulatory dysfunctions in patients with menstrual disorders. J Clin Endocrinol Metab. 2001; 86(1):135-9. DOI: 10.1210/jcem.86.1.7098. View

13.

Graham J, Clarke C . Physiological action of progesterone in target tissues. Endocr Rev. 1997; 18(4):502-19. DOI: 10.1210/edrv.18.4.0308. View

14.

Guo L, Liu X, Qin D, Gao L, Zhang H, Liu J . [Effects of nanosized titanium dioxide on the reproductive system of male mice]. Zhonghua Nan Ke Xue. 2009; 15(6):517-22. View

15.

Gao G, Ze Y, Li B, Zhao X, Zhang T, Sheng L . Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticles. J Hazard Mater. 2012; 243:19-27. DOI: 10.1016/j.jhazmat.2012.08.049. View

16.

Brodin T, Bergh T, Berglund L, Hadziosmanovic N, Holte J . High basal LH levels in combination with low basal FSH levels are associated with high success rates at assisted reproduction. Hum Reprod. 2009; 24(11):2755-9. DOI: 10.1093/humrep/dep254. View

17.

Ishizuka B, Kudo Y, Amemiya A, Yamada H, Matsuda T, Ogata T . Anti-nuclear antibodies in patients with premature ovarian failure. Hum Reprod. 1999; 14(1):70-5. DOI: 10.1093/humrep/14.1.70. View

18.

Hong F, Zhao X, Si W, Ze Y, Wang L, Zhou Y . Decreased spermatogenesis led to alterations of testis-specific gene expression in male mice following nano-TiO2 exposure. J Hazard Mater. 2015; 300:718-728. DOI: 10.1016/j.jhazmat.2015.08.010. View

19.

McElduff A, Morris J . Thyroid function tests and thyroid autoantibodies in an unselected population of women undergoing first trimester screening for aneuploidy. Aust N Z J Obstet Gynaecol. 2008; 48(5):478-80. DOI: 10.1111/j.1479-828X.2008.00903.x. View

20.

Erdem A, Erdem M, Atmaca S, Guler I . Impact of luteal phase support on pregnancy rates in intrauterine insemination cycles: a prospective randomized study. Fertil Steril. 2008; 91(6):2508-13. DOI: 10.1016/j.fertnstert.2008.04.029. View