Xanthelasma: An Update on Treatment Modalities

Overview

Journal J Cutan Aesthet Surg

Date 2018 May 8

PMID 29731585

Citations 7

Authors

Zainab Laftah

Firas Al-Niaimi

Affiliations

Soon will be listed here.

Abstract

Xanthelasmas are localized accumulation of lipid deposits on the eyelids. Lesions are typically asymptomatic and treatment is often sought for cosmetic purposes. Unfortunately, there is paucity of strong evidence in the literature for the effective treatment of normolipidemic xanthelasmas. A literature search using the term "xanthelasma" was carried out in PubMed and Medline databases. Only articles related to treatment were considered and analyzed for their data. Commonly cited treatments include topical trichloroacetic acid, liquid nitrogen cryotherapy, and various lasers including carbon dioxide, Er:YAG, Q-switched Nd:YAG, and pulse dye laser. However, traditional surgical excision has also been used. This article reviews these currently accepted modalities of treatment.

Citing Articles

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A scoring-based clinical grading model for xanthelasma palpebrarum: predicting treatment frequency and prognosis.

Xu Q, Yao Z, Yu X, Ying J, Zhu J, Lu L Arch Dermatol Res. 2024; 316(8):614.

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Surgical removal of multiple xanthomas in familial hypercholesterolemia: a case report.

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References

Lee H, Jin U, Minn K, Park Y . Outcomes of surgical management of xanthelasma palpebrarum. Arch Plast Surg. 2013; 40(4):380-6. PMC: 3723999. DOI: 10.5999/aps.2013.40.4.380. View

Hubert H, Feinleib M, MCNAMARA P, CASTELLI W . Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983; 67(5):968-77. DOI: 10.1161/01.cir.67.5.968. View

Klor H, Weizel A, Augustin M, Diepgen T, Elsner P, Homey B . The impact of oral vitamin A derivatives on lipid metabolism - What recommendations can be derived for dealing with this issue in the daily dermatological practice?. J Dtsch Dermatol Ges. 2011; 9(8):600-6. DOI: 10.1111/j.1610-0387.2011.07637.x. View

Apfelberg D, Maser M, Lash H, White D . Treatment of xanthelasma palpebrarum with the carbon dioxide laser. J Dermatol Surg Oncol. 1987; 13(2):149-51. DOI: 10.1111/j.1524-4725.1987.tb00512.x. View

Bergman R . The pathogenesis and clinical significance of xanthelasma palpebrarum. J Am Acad Dermatol. 1994; 30(2 Pt 1):236-42. DOI: 10.1016/s0190-9622(94)70023-0. View

Kaufmann R, Hibst R . Pulsed Erbium:YAG laser ablation in cutaneous surgery. Lasers Surg Med. 1996; 19(3):324-30. DOI: 10.1002/(SICI)1096-9101(1996)19:3<324::AID-LSM7>3.0.CO;2-U. View

Ullmann Y, Har-Shai Y, Peled I . The use of CO2 laser for the treatment of xanthelasma palpebrarum. Ann Plast Surg. 1993; 31(6):504-7. DOI: 10.1097/00000637-199312000-00005. View

Mourad B, Elgarhy L, Ellakkawy H, ElMahdy N . Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum. J Cosmet Dermatol. 2015; 14(3):209-15. DOI: 10.1111/jocd.12148. View

Gungor S, Canat D, Gokdemir G . Erbium: YAG laser ablation versus 70% trichloroacetıc acid application in the treatment of xanthelasma palpebrarum. J Dermatolog Treat. 2013; 25(4):290-3. DOI: 10.3109/09546634.2013.777153. View

10.

Reddy P, Kunneth S, Lakshminarayana S, Yallappa S, Chandrashekara R, Nanjundaswamy S . Comparative Study to Evaluate the Efficacy of Radiofrequency Ablation versus Trichloroacetic Acid in the Treatment of Xanthelasma Palpebrarum. J Cutan Aesthet Surg. 2017; 9(4):236-240. PMC: 5227076. DOI: 10.4103/0974-2077.197073. View

11.

Karsai S, Czarnecka A, Raulin C . Treatment of xanthelasma palpebrarum using a pulsed dye laser: a prospective clinical trial in 38 cases. Dermatol Surg. 2010; 36(5):610-7. DOI: 10.1111/j.1524-4725.2010.01514.x. View

12.

Mannino G, Papale A, De Bella F, Mollo R, Morgia P, Gabrieli C . Use of Erbium:YAG laser in the treatment of palpebral xanthelasmas. Ophthalmic Surg Lasers. 2001; 32(2):129-33. View

13.

Fusade T . Treatment of xanthelasma palpebrarum by 1064-nm Q-switched Nd:YAG laser: a study of 11 cases. Br J Dermatol. 2007; 158(1):84-7. DOI: 10.1111/j.1365-2133.2007.08194.x. View

14.

Civeira F, Perez-Calahorra S, Mateo-Gallego R . Rapid resolution of xanthelasmas after treatment with alirocumab. J Clin Lipidol. 2016; 10(5):1259-61. DOI: 10.1016/j.jacl.2016.07.007. View

15.

Zak A, Zeman M, Slaby A, Vecka M . Xanthomas: clinical and pathophysiological relations. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014; 158(2):181-8. DOI: 10.5507/bp.2014.016. View

16.

Abdelkader M, Alashry S . Argon laser versus erbium:YAG laser in the treatment of xanthelasma palpebrarum. Saudi J Ophthalmol. 2015; 29(2):116-20. PMC: 4398792. DOI: 10.1016/j.sjopt.2014.09.017. View

17.

Smellie W . Hypertriglyceridaemia in diabetes. BMJ. 2006; 333(7581):1257-60. PMC: 1702429. DOI: 10.1136/bmj.39043.398738.DE. View

18.

HARRIS Jr R, GILMORE 3rd H, Bricker L, KIEM I, Rubin E . Long-term oral administration of probucol (4,4'-(isopropylidenedithio) bis(2,6-di-t-butylphenol)) (DH-581) in the management of hypercholesterolemia. J Am Geriatr Soc. 1974; 22(4):167-75. DOI: 10.1111/j.1532-5415.1974.tb02163.x. View

19.

Labandeira J, Vazquez-Osorio I, Figueroa-Silva O, Pereiro Jr M, Toribio J . Tolerability and effectiveness of liquid nitrogen spray cryotherapy with very short freeze times in the treatment of xanthelasma palpebrarum. Dermatol Ther. 2015; 28(6):346-50. DOI: 10.1111/dth.12254. View

20.

Walsh B, SCHIFF I, Rosner B, Greenberg L, Ravnikar V, Sacks F . Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med. 1991; 325(17):1196-204. DOI: 10.1056/NEJM199110243251702. View