Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago

Overview

Journal AIDS Behav

Specialty Infectious Diseases

Date 2018 May 6

PMID 29728949

Citations 37

Authors

Ethan Morgan

Kevin Moran

Daniel T Ryan

Brian Mustanski

Michael E Newcomb

Affiliations

Soon will be listed here.

Abstract

The goal of this work is to better understand utilization and uptake of pre-exposure prophylaxis (PrEP) among young men who have sex with men (YMSM) and transgender women (TGW). We assessed trends and correlates of PrEP use and adherence across three time points of longitudinal data collection among 885 YMSM and TGW (aged 16-29) from the RADAR cohort in Chicago, 2015-2017. Past 6-month PrEP use increased across three visits: from 6.6 to 17.5%. In multivariable models, past 6-month PrEP use was significantly associated with participation in condomless sex, having more sexual partners, and older age. At least three-quarters of current PrEP users reported being ≥ 90% adherent to PrEP medication across all visits. Past 6-month PrEP use increased over time with those who participated in high-risk HIV behaviors also those most likely to have taken PrEP. As PrEP uptake continues to rise, more research will be needed to understand predictors of PrEP usage, as well as patterns of sexual behavior change following uptake.

Citing Articles

PrEP Awareness and Coverage: Results from the 2022 South Africa Antenatal HIV Sentinel Survey.

Shangase N, Kufa T, Cheyip M, Puren A AIDS Behav. 2025; .

PMID: 39939480 DOI: 10.1007/s10461-024-04609-3.

Randomized controlled trial of a pilot PrEP linkage intervention for individuals leaving incarceration in a southern state: Design and baseline characteristics.

Horton H, Marshall S, Gu M, Tody B, Jackson T, Zaller N PLoS One. 2024; 19(12):e0312667.

PMID: 39621654 PMC: 11611198. DOI: 10.1371/journal.pone.0312667.

Preferences for Starting Daily, On-Demand, and Long-Acting Injectable HIV Preexposure Prophylaxis Among Men Who Have Sex With Men in the United States (2021-2022): Nationwide Online Cross-Sectional Study.

Islek D, Sanchez T, Glick J, Jones J, Rawlings K, Sarkar S JMIR Public Health Surveill. 2024; 10():e62801.

PMID: 39536313 PMC: 11602762. DOI: 10.2196/62801.

Psychosocial Barriers to Pre-exposure Prophylaxis (PrEP) Uptake: The Roles of Heterosexual Self-Presentation, Sexual Risk, and Perceived Peer PrEP Use.

Parent M, Woznicki N, Dillon F, Pituch K Psychol Men Masc. 2024; 21(4):699-703.

PMID: 38464395 PMC: 10923563. DOI: 10.1037/men0000258.

Uptake and Persistence on HIV Pre-Exposure Prophylaxis Among Female Sex Workers and Men Having Sex with Men in Kigali, Rwanda: A Retrospective Cross-Sectional Study Design.

Rugira E, Biracyaza E, Umubyeyi A Patient Prefer Adherence. 2023; 17:2353-2364.

PMID: 37790862 PMC: 10542111. DOI: 10.2147/PPA.S427021.

References

Gerend M, Newcomb M, Mustanski B . Prevalence and correlates of smoking and e-cigarette use among young men who have sex with men and transgender women. Drug Alcohol Depend. 2017; 179:395-399. PMC: 5599370. DOI: 10.1016/j.drugalcdep.2017.07.022. View

Baxi S, Liu A, Bacchetti P, Mutua G, Sanders E, Kibengo F . Comparing the novel method of assessing PrEP adherence/exposure using hair samples to other pharmacologic and traditional measures. J Acquir Immune Defic Syndr. 2014; 68(1):13-20. PMC: 4262724. DOI: 10.1097/QAI.0000000000000386. View

Grant R, Anderson P, McMahan V, Liu A, Amico K, Mehrotra M . Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis. 2014; 14(9):820-9. PMC: 6107918. DOI: 10.1016/S1473-3099(14)70847-3. View

Newcomb M, Moran K, Feinstein B, Forscher E, Mustanski B . Pre-Exposure Prophylaxis (PrEP) Use and Condomless Anal Sex: Evidence of Risk Compensation in a Cohort of Young Men Who Have Sex with Men. J Acquir Immune Defic Syndr. 2017; 77(4):358-364. PMC: 5825266. DOI: 10.1097/QAI.0000000000001604. View

Golub S, Kowalczyk W, Weinberger C, Parsons J . Preexposure prophylaxis and predicted condom use among high-risk men who have sex with men. J Acquir Immune Defic Syndr. 2010; 54(5):548-55. PMC: 2908204. DOI: 10.1097/QAI.0b013e3181e19a54. View

Bauermeister J, Meanley S, Pingel E, Soler J, Harper G . PrEP awareness and perceived barriers among single young men who have sex with men. Curr HIV Res. 2014; 11(7):520-7. PMC: 4152728. DOI: 10.2174/1570162x12666140129100411. View

Mimiaga M, Case P, Johnson C, Safren S, Mayer K . Preexposure antiretroviral prophylaxis attitudes in high-risk Boston area men who report having sex with men: limited knowledge and experience but potential for increased utilization after education. J Acquir Immune Defic Syndr. 2009; 50(1):77-83. PMC: 2659469. DOI: 10.1097/QAI.0b013e31818d5a27. View

Mustanski B, Swann G, Newcomb M, Prachand N . Effects of Parental Monitoring and Knowledge on Substance Use and HIV Risk Behaviors Among Young Men Who have Sex with Men: Results from Three Studies. AIDS Behav. 2017; 21(7):2046-2058. PMC: 5804483. DOI: 10.1007/s10461-017-1761-2. View

Eaton L, Matthews D, Driffin D, Bukowski L, Wilson P, Stall R . A Multi-US City Assessment of Awareness and Uptake of Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Black Men and Transgender Women Who Have Sex with Men. Prev Sci. 2017; 18(5):505-516. PMC: 5926200. DOI: 10.1007/s11121-017-0756-6. View

10.

Giordano T, Guzman D, Clark R, Charlebois E, Bangsberg D . Measuring adherence to antiretroviral therapy in a diverse population using a visual analogue scale. HIV Clin Trials. 2004; 5(2):74-9. DOI: 10.1310/JFXH-G3X2-EYM6-D6UG. View

11.

Goedel W, Halkitis P, Greene R, Duncan D . Correlates of Awareness of and Willingness to Use Pre-exposure Prophylaxis (PrEP) in Gay, Bisexual, and Other Men Who Have Sex with Men Who Use Geosocial-Networking Smartphone Applications in New York City. AIDS Behav. 2016; 20(7):1435-42. DOI: 10.1007/s10461-016-1353-6. View

12.

Eaton L, Driffin D, Bauermeister J, Smith H, Conway-Washington C . Minimal Awareness and Stalled Uptake of Pre-Exposure Prophylaxis (PrEP) Among at Risk, HIV-Negative, Black Men Who Have Sex with Men. AIDS Patient Care STDS. 2015; 29(8):423-9. PMC: 4601552. DOI: 10.1089/apc.2014.0303. View

13.

Sullivan P, Rosenberg E, Sanchez T, Kelley C, Luisi N, Cooper H . Explaining racial disparities in HIV incidence in black and white men who have sex with men in Atlanta, GA: a prospective observational cohort study. Ann Epidemiol. 2015; 25(6):445-54. PMC: 4433604. DOI: 10.1016/j.annepidem.2015.03.006. View

14.

van der Straten A, Brown E, Marrazzo J, Chirenje M, Liu K, Gomez K . Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN-003 (VOICE) study. J Int AIDS Soc. 2016; 19(1):20642. PMC: 4744323. DOI: 10.7448/IAS.19.1.20642. View

15.

Saunders J, Aasland O, Babor T, De la Fuente J, Grant M . Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. Addiction. 1993; 88(6):791-804. DOI: 10.1111/j.1360-0443.1993.tb02093.x. View

16.

Grant R, Lama J, Anderson P, McMahan V, Liu A, Vargas L . Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010; 363(27):2587-99. PMC: 3079639. DOI: 10.1056/NEJMoa1011205. View

17.

Johnson B, Redding C, DiClemente R, Mustanski B, Dodge B, Sheeran P . A network-individual-resource model for HIV prevention. AIDS Behav. 2010; 14(Suppl 2):204-21. PMC: 4361779. DOI: 10.1007/s10461-010-9803-z. View

18.

Miyazaki Y, Raudenbush S . Tests for linkage of multiple cohorts in an accelerated longitudinal design. Psychol Methods. 2000; 5(1):44-63. DOI: 10.1037/1082-989x.5.1.44. View

19.

Amico K, Mehrotra M, Avelino-Silva V, McMahan V, Veloso V, Anderson P . Self-reported Recent PrEP Dosing and Drug Detection in an Open Label PrEP Study. AIDS Behav. 2016; 20(7):1535-40. PMC: 4903107. DOI: 10.1007/s10461-016-1360-7. View

20.

Adamson S, Kay-Lambkin F, Baker A, Lewin T, Thornton L, Kelly B . An improved brief measure of cannabis misuse: the Cannabis Use Disorders Identification Test-Revised (CUDIT-R). Drug Alcohol Depend. 2010; 110(1-2):137-43. DOI: 10.1016/j.drugalcdep.2010.02.017. View