Practical Consensus Recommendations Regarding the Management of Hormone Receptor Positive Early Breast Cancer in Elderly Women

Overview

Journal South Asian J Cancer

Specialty Oncology

Date 2018 May 4

PMID 29721478

Citations 1

Authors

Govind Babu

A Goel

S Agarwal

S Gupta

P Kumar

B K Smruti

V Goel

R Sarangi

M Gairola

S Aggarwal

Purvish M Parikh

Affiliations

Soon will be listed here.

Abstract

Breast cancer is a leading cause of death among women, and its incidence increases with age. Currently the treatment of breast cancer in older patients is almost identical to their younger counterparts. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at these practical consensus recommendations for the benefit of community oncologists regarding the management of early breast cancer specifically in elderly women.

Citing Articles

A quality evaluation of the clinical practice guidelines on breast cancer using the RIGHT checklist.

Zhou H, Chen H, Cheng C, Wu X, Ma Y, Han J Ann Transl Med. 2021; 9(14):1174.

PMID: 34430615 PMC: 8350626. DOI: 10.21037/atm-21-2884.

References

Martin M, Prat A, Rodriguez-Lescure A, Caballero R, Ebbert M, Munarriz B . PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer. Breast Cancer Res Treat. 2013; 138(2):457-66. PMC: 3608881. DOI: 10.1007/s10549-013-2416-2. View

Yersal O, Barutca S . Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol. 2014; 5(3):412-24. PMC: 4127612. DOI: 10.5306/wjco.v5.i3.412. View

Crivellari D, Price K, Gelber R, Castiglione-Gertsch M, Rudenstam C, Lindtner J . Adjuvant endocrine therapy compared with no systemic therapy for elderly women with early breast cancer: 21-year results of International Breast Cancer Study Group Trial IV. J Clin Oncol. 2003; 21(24):4517-23. DOI: 10.1200/JCO.2003.03.559. View

Berry D, Cirrincione C, Henderson I, Citron M, Budman D, Goldstein L . Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA. 2006; 295(14):1658-67. PMC: 1459540. DOI: 10.1001/jama.295.14.1658. View

Ellis P, Smith I, Detre S, Burton S, Salter J, AHern R . Reduced apoptosis and proliferation and increased Bcl-2 in residual breast cancer following preoperative chemotherapy. Breast Cancer Res Treat. 1998; 48(2):107-16. DOI: 10.1023/a:1005933815809. View

Kiderlen M, Bastiaannet E, Walsh P, Keating N, Schrodi S, Engel J . Surgical treatment of early stage breast cancer in elderly: an international comparison. Breast Cancer Res Treat. 2011; 132(2):675-82. PMC: 3303082. DOI: 10.1007/s10549-011-1892-5. View

Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V . Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005; 366(9503):2087-106. DOI: 10.1016/S0140-6736(05)67887-7. View

VanderWalde A, Hurria A . Early breast cancer in the older woman. Clin Geriatr Med. 2012; 28(1):73-91. PMC: 3874410. DOI: 10.1016/j.cger.2011.10.002. View

Bottini A, Berruti A, Bersiga A, Brizzi M, Bruzzi P, Aguggini S . Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer. Br J Cancer. 2001; 85(8):1106-12. PMC: 2375158. DOI: 10.1054/bjoc.2001.2048. View

10.

Burdette-Radoux S, Muss H . Adjuvant chemotherapy in the elderly: whom to treat, what regimen?. Oncologist. 2006; 11(3):234-42. DOI: 10.1634/theoncologist.11-3-234. View

11.

Bertucci F, Birnbaum D . Reasons for breast cancer heterogeneity. J Biol. 2008; 7(2):6. PMC: 2263121. DOI: 10.1186/jbiol67. View

12.

Bottini A, Berruti A, Bersiga A, Brunelli A, Brizzi M, Marco B . Effect of neoadjuvant chemotherapy on Ki67 labelling index, c-erbB-2 expression and steroid hormone receptor status in human breast tumours. Anticancer Res. 1996; 16(5B):3105-10. View

13.

Smith B, Gross C, Smith G, Galusha D, Bekelman J, Haffty B . Effectiveness of radiation therapy for older women with early breast cancer. J Natl Cancer Inst. 2006; 98(10):681-90. DOI: 10.1093/jnci/djj186. View

14.

. Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 1998; 351(9114):1451-67. View

15.

de Azambuja E, Cardoso F, de Castro Jr G, Colozza M, Mano M, Durbecq V . Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients. Br J Cancer. 2007; 96(10):1504-13. PMC: 2359936. DOI: 10.1038/sj.bjc.6603756. View

16.

Giordano S, Duan Z, Kuo Y, Hortobagyi G, Goodwin J . Use and outcomes of adjuvant chemotherapy in older women with breast cancer. J Clin Oncol. 2006; 24(18):2750-6. DOI: 10.1200/JCO.2005.02.3028. View

17.

Cheang M, Voduc K, Tu D, Jiang S, Leung S, Chia S . Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial. Clin Cancer Res. 2012; 18(8):2402-12. PMC: 3743660. DOI: 10.1158/1078-0432.CCR-11-2956. View

18.

Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M . Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011; 378(9804):1707-16. PMC: 3254252. DOI: 10.1016/S0140-6736(11)61629-2. View

19.

Gazet J, Ford H, Coombes R, Bland J, Sutcliffe R, Quilliam J . Prospective randomized trial of tamoxifen vs surgery in elderly patients with breast cancer. Eur J Surg Oncol. 1994; 20(3):207-14. View

20.

Makris A, Powles T, Allred D, Ashley S, Ormerod M, Titley J . Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response. Breast Cancer Res Treat. 1998; 48(1):11-20. DOI: 10.1023/a:1005973529921. View