Surface Impact on Nanoparticle-based Magnetic Resonance Imaging Contrast Agents

Overview

Journal Theranostics

Date 2018 May 4

PMID 29721097

Citations 42

Authors

Weizhong Zhang

Lin Liu

Hongmin Chen

Kai Hu

Ian Delahunty

Shi Gao

Jin Xie

Affiliations

Soon will be listed here.

Abstract

Magnetic resonance imaging (MRI) is one of the most widely used diagnostic tools in the clinic. To improve imaging quality, MRI contrast agents, which can modulate local T and T relaxation times, are often injected prior to or during MRI scans. However, clinically used contrast agents, including Gd-based chelates and iron oxide nanoparticles (IONPs), afford mediocre contrast abilities. To address this issue, there has been extensive research on developing alternative MRI contrast agents with superior r and r relaxivities. These efforts are facilitated by the fast progress in nanotechnology, which allows for preparation of magnetic nanoparticles (NPs) with varied size, shape, crystallinity, and composition. Studies suggest that surface coatings can also largely affect T and T relaxations and can be tailored in favor of a high r or r. However, the surface impact of NPs has been less emphasized. Herein, we review recent progress on developing NP-based T and T contrast agents, with a focus on the surface impact.

Citing Articles

Iron Oxide Nanoparticle-Based T Contrast Agents for Magnetic Resonance Imaging: A Review.

Zhang D, Zhang J, Bian X, Zhang P, Wu W, Zuo X Nanomaterials (Basel). 2025; 15(1.

PMID: 39791792 PMC: 11722098. DOI: 10.3390/nano15010033.

Ion carrier modulated MRI contrast.

Duncan A, Ellis C, Levingston H, Kerckhoffs A, Mozes F, Langton M Chem Sci. 2024; .

PMID: 39129769 PMC: 11310829. DOI: 10.1039/d3sc03466f.

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile.

Ferreira-Filho V, Morais B, Vieira B, Waerenborgh J, Carmezim M, Toth C Molecules. 2024; 29(8).

PMID: 38675647 PMC: 11052394. DOI: 10.3390/molecules29081824.

Protease-Mediated Contrast Enhancement of Multilayered Magneto-Gadolinium Nanostructures for Imaging and Magnetic Hyperthermia.

Avugadda S, Soni N, Rodrigues E, Persano S, Pellegrino T ACS Appl Mater Interfaces. 2024; 16(6):6743-6755.

PMID: 38295315 PMC: 10875642. DOI: 10.1021/acsami.3c13914.

Current status of Fe-based MOFs in biomedical applications.

Yang H, Liao D, Cai Z, Zhang Y, Nezamzadeh-Ejhieh A, Zheng M RSC Med Chem. 2023; 14(12):2473-2495.

PMID: 38107167 PMC: 10718519. DOI: 10.1039/d3md00416c.

References

Sitharaman B, Kissell K, Hartman K, Tran L, Baikalov A, Rusakova I . Superparamagnetic gadonanotubes are high-performance MRI contrast agents. Chem Commun (Camb). 2005; (31):3915-7. DOI: 10.1039/b504435a. View

Hooker J, Datta A, Botta M, Raymond K, Francis M . Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Nano Lett. 2007; 7(8):2207-10. DOI: 10.1021/nl070512c. View

Zhou Z, Lu Z . Gadolinium-based contrast agents for magnetic resonance cancer imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012; 5(1):1-18. PMC: 3552562. DOI: 10.1002/wnan.1198. View

Kamaly N, Kalber T, Ahmad A, Oliver M, So P, Herlihy A . Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging. Bioconjug Chem. 2007; 19(1):118-29. DOI: 10.1021/bc7001715. View

Huang C, Khu N, Yeh C . The characteristics of sub 10 nm manganese oxide T1 contrast agents of different nanostructured morphologies. Biomaterials. 2010; 31(14):4073-8. DOI: 10.1016/j.biomaterials.2010.01.087. View

Park J, An K, Hwang Y, Park J, Noh H, Kim J . Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater. 2004; 3(12):891-5. DOI: 10.1038/nmat1251. View

Barry Delongchamps N, Rouanne M, Flam T, Beuvon F, Liberatore M, Zerbib M . Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging. BJU Int. 2010; 107(9):1411-8. DOI: 10.1111/j.1464-410X.2010.09808.x. View

Richard C, Doan B, Beloeil J, Bessodes M, Toth E, Scherman D . Noncovalent functionalization of carbon nanotubes with amphiphilic gd3+ chelates: toward powerful t1 and t2 MRI contrast agents. Nano Lett. 2007; 8(1):232-6. DOI: 10.1021/nl072509z. View

Caravan P . Strategies for increasing the sensitivity of gadolinium based MRI contrast agents. Chem Soc Rev. 2006; 35(6):512-23. DOI: 10.1039/b510982p. View

10.

Yang K, Hu L, Ma X, Ye S, Cheng L, Shi X . Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Adv Mater. 2012; 24(14):1868-72. DOI: 10.1002/adma.201104964. View

11.

Ghaghada K, Ravoori M, Sabapathy D, Bankson J, Kundra V, Annapragada A . New dual mode gadolinium nanoparticle contrast agent for magnetic resonance imaging. PLoS One. 2009; 4(10):e7628. PMC: 2764087. DOI: 10.1371/journal.pone.0007628. View

12.

Hegde J, Mulkern R, Panych L, Fennessy F, Fedorov A, Maier S . Multiparametric MRI of prostate cancer: an update on state-of-the-art techniques and their performance in detecting and localizing prostate cancer. J Magn Reson Imaging. 2013; 37(5):1035-54. PMC: 3741996. DOI: 10.1002/jmri.23860. View

13.

Swanson S, Kukowska-Latallo J, Patri A, Chen C, Ge S, Cao Z . Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. Int J Nanomedicine. 2008; 3(2):201-10. PMC: 2527674. View

14.

Thu M, Bryant L, Coppola T, Jordan E, Budde M, Lewis B . Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging. Nat Med. 2012; 18(3):463-7. PMC: 3296876. DOI: 10.1038/nm.2666. View

15.

Jafari A, Salouti M, Farjami Shayesteh S, Heidari Z, Bitarafan Rajabi A, Boustani K . Synthesis and characterization of Bombesin-superparamagnetic iron oxide nanoparticles as a targeted contrast agent for imaging of breast cancer using MRI. Nanotechnology. 2015; 26(7):075101. DOI: 10.1088/0957-4484/26/7/075101. View

16.

Ruiz-Cabello J, Barnett B, Bottomley P, Bulte J . Fluorine (19F) MRS and MRI in biomedicine. NMR Biomed. 2010; 24(2):114-29. PMC: 3051284. DOI: 10.1002/nbm.1570. View

17.

Lu A, Salabas E, Schuth F . Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed Engl. 2007; 46(8):1222-44. DOI: 10.1002/anie.200602866. View

18.

Frias J, Williams K, Fisher E, Fayad Z . Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J Am Chem Soc. 2004; 126(50):16316-7. DOI: 10.1021/ja044911a. View

19.

Gianolio E, Giovenzana G, Longo D, Longo I, Menegotto I, Aime S . Relaxometric and modelling studies of the binding of a lipophilic Gd-AAZTA complex to fatted and defatted human serum albumin. Chemistry. 2007; 13(20):5785-97. DOI: 10.1002/chem.200601277. View

20.

Andrec M, Montelione G, Levy R . Estimation of dynamic parameters from NMR relaxation data using the Lipari-Szabo model-free approach and Bayesian statistical methods. J Magn Reson. 1999; 139(2):408-21. DOI: 10.1006/jmre.1999.1839. View