Correlation Analysis Between the Chemical Contents and Bioactivity for the Quality Control of Alismatis Rhizoma

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2018 May 3

PMID 29719785

Citations 6

Authors

Xiaoxv Gao

Chengpeng Sun

Zhenglong Yu

Jian Cang

Xiangge Tian

Xiaokui Huo

Lei Feng

Xinguang Liu

Chao Wang

Baojing Zhang

Xiaochi Ma

Affiliations

Soon will be listed here.

Abstract

In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC-PDA, HPLC-VWD and UHPLC-MS , combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated . PLSR analysis revealed significant positive correlations ( = 0.5795) between the contents of triterpenes , , , and and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production.

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