Injectable Hyperbranched Poly(β-amino Ester) Hydrogels with On-demand Degradation Profiles to Match Wound Healing Processes

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 May 3

PMID 29719691

Citations 24

Authors

Qian Xu

Linru Guo

Sigen A

Yongsheng Gao

Dezhong Zhou

Udo Greiser

Jack Creagh-Flynn

Hong Zhang

Yixiao Dong

Lara Cutlar

Fagang Wang

Wenguang Liu

Wei Wang

Wenxin Wang

Affiliations

Soon will be listed here.

Abstract

Adjusting biomaterial degradation profiles to match tissue regeneration is a challenging issue. Herein, biodegradable hyperbranched poly(β-amino ester)s (HP-PBAEs) were designed and synthesized "A2 + B4" Michael addition polymerization, and displayed fast gelation with thiolated hyaluronic acid (HA-SH) a "click" thiol-ene reaction. HP-PBAE/HA-SH hydrogels showed tunable degradation profiles both and using diamines with different alkyl chain lengths and poly(ethylene glycol) diacrylates with varied PEG spacers. The hydrogels with optimized degradation profiles encapsulating ADSCs were used as injectable hydrogels to treat two different types of humanized excisional wounds - acute wounds with faster healing rates and diabetic wounds with slower healing and neo-tissue formation. The fast-degrading hydrogel showed accelerated wound closure in acute wounds, while the slow-degrading hydrogel showed better wound healing for diabetic wounds. The results demonstrate that the new HP-PBAE-based hydrogel in combination with ADSCs can be used as a well-controlled biodegradable skin substitute, which demonstrates a promising approach in the treatment of various types of skin wounds.

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