The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Overview

Journal Front Pharmacol

Date 2018 May 3

PMID 29719508

Citations 72

Authors

Sabina Janciauskiene

Sabine Wrenger

Stephan Immenschuh

Beata Olejnicka

Timm Greulich

Tobias Welte

Joanna Chorostowska-Wynimko

Affiliations

Soon will be listed here.

Abstract

Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.

Citing Articles

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