Siloxyalkyne-Alkene Metathesis: Rapid Access to Highly Functionalized Enones

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 May 2

PMID 29712103

Citations 8

Authors

Michael P Schramm

D Srinivasa Reddy

Sergey A Kozmin

Affiliations

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Abstract

Mechanistically intriguing participation of siloxyalkynes occurs in the intramolecular Ru-catalyzed metathesis with terminal alkenes (see scheme; Ms=methanesulfonyl). Combined with efficient protodesilylation, this process resulted in the development of a new method for the synthesis of highly functionalized enones starting from readily accessible acyclic precursors. Heterocyclic and polycyclic compounds were prepared efficiently, which illustrates the generality of this novel method.

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