Synthesis, Spectroscopic Identification and Molecular Docking of Certain -(2-{[2-(1-Indol-2-ylcarbonyl) Hydrazinyl](oxo)Acetylphenyl)Acetamides and -[2-(2-{[2-(Acetylamino)Phenyl](oxo)Acetylhydrazinyl)-2-Oxoethyl]-1-Indole-2-Carboxamides: New...

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 May 2

PMID 29710842

Citations 2

Authors

Maha S Almutairi

Azza S Zakaria

Reem I Al-Wabli

I Hubert Joe

Ali S Abdelhameed

Mohamed I Attia

Affiliations

Soon will be listed here.

Abstract

-(2-{[2-(1-Indol-2-ylcarbonyl)hydrazinyl](oxo)acetyl}phenyl)acetamides () and -[2-(2-{[2-(acetylamino)phenyl](oxo)acetyl}hydrazinyl)-2-oxoethyl]-1-indole-2-carboxamides () were synthesized and characterized with different analytical tools. -Acetylisatines were subjected to ring opening at their C2 carbons with the aid of different indole-bearing hydrazides and to afford the respective glyoxylamides . The antimicrobial activity of the target compounds was assessed with the aid of Diameter of the Inhibition Zone (DIZ) and Minimum Inhibitory Concentration (MIC) assays against a panel of Gram-positive and Gram-negative bacteria and certain fungal strains. The antimicrobial screening revealed that , , and are the most sensitive microorganisms towards the synthesized compounds . In addition, compounds and emerged as the most active congeners towards and , respectively. Molecular docking studies revealed the possible binding mode of compounds and to their target proteins.

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