The Neuroanatomic Complexity of the CRF and DA Systems and Their Interface: What We Still Don't Know

Overview

Journal Neurosci Biobehav Rev

Specialties Neurology
Psychology
Social Sciences

Date 2018 Apr 29

PMID 29704516

Citations 15

Authors

E A Kelly

J L Fudge

Affiliations

Soon will be listed here.

Abstract

Corticotropin-releasing factor (CRF) is a neuropeptide that mediates the stress response. Long known to contribute to regulation of the adrenal stress response initiated in the hypothalamic-pituitary axis (HPA), a complex pattern of extrahypothalamic CRF expression is also described in rodents and primates. Cross-talk between the CRF and midbrain dopamine (DA) systems links the stress response to DA regulation. Classically CRF + cells in the extended amygdala and paraventricular nucleus (PVN) are considered the main source of this input, principally targeting the ventral tegmental area (VTA). However, the anatomic complexity of both the DA and CRF system has been increasingly elaborated in the last decade. The DA neurons are now recognized as having diverse molecular, connectional and physiologic properties, predicted by their anatomic location. At the same time, the broad distribution of CRF cells in the brain has been increasingly delineated using different species and techniques. Here, we review updated information on both CRF localization and newer conceptualizations of the DA system to reconsider the CRF-DA interface.

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References

Wise R, Morales M . A ventral tegmental CRF-glutamate-dopamine interaction in addiction. Brain Res. 2009; 1314:38-43. PMC: 2819620. DOI: 10.1016/j.brainres.2009.09.101. View

Lerner T, Shilyansky C, Davidson T, Evans K, Beier K, Zalocusky K . Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits. Cell. 2015; 162(3):635-47. PMC: 4790813. DOI: 10.1016/j.cell.2015.07.014. View

Chang D, Yi S, Baram T . Developmental profile of corticotropin releasing hormone messenger RNA in the rat inferior olive. Int J Dev Neurosci. 1996; 14(1):69-76. PMC: 3477861. DOI: 10.1016/0736-5748(95)00072-0. View

Kalivas P, Duffy P, Latimer L . Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat. J Pharmacol Exp Ther. 1987; 242(3):757-63. View

Carlsen J, Heimer L . The basolateral amygdaloid complex as a cortical-like structure. Brain Res. 1988; 441(1-2):377-80. DOI: 10.1016/0006-8993(88)91418-7. View

Sakanaka M, Shibasaki T, Lederis K . Corticotropin-releasing factor-containing afferents to the inferior colliculus of the rat brain. Brain Res. 1987; 414(1):68-76. DOI: 10.1016/0006-8993(87)91326-6. View

Joels M, Baram T . The neuro-symphony of stress. Nat Rev Neurosci. 2009; 10(6):459-66. PMC: 2844123. DOI: 10.1038/nrn2632. View

Nahon J, Presse F, Bittencourt J, Sawchenko P, Vale W . The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinology. 1989; 125(4):2056-65. DOI: 10.1210/endo-125-4-2056. View

Asan E, Yilmazer-Hanke D, Eliava M, Hantsch M, Lesch K, Schmitt A . The corticotropin-releasing factor (CRF)-system and monoaminergic afferents in the central amygdala: investigations in different mouse strains and comparison with the rat. Neuroscience. 2005; 131(4):953-67. DOI: 10.1016/j.neuroscience.2004.11.040. View

10.

Foote S, Cha C . Distribution of corticotropin-releasing-factor-like immunoreactivity in brainstem of two monkey species (Saimiri sciureus and Macaca fascicularis): an immunohistochemical study. J Comp Neurol. 1988; 276(2):239-64. DOI: 10.1002/cne.902760208. View

11.

Root D, Hoffman A, Good C, Zhang S, Gigante E, Lupica C . Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015; 35(8):3460-9. PMC: 4339355. DOI: 10.1523/JNEUROSCI.4525-13.2015. View

12.

Haber S, Ryoo H, Cox C, Lu W . Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. J Comp Neurol. 1995; 362(3):400-10. DOI: 10.1002/cne.903620308. View

13.

Yadid G, Friedman A . Dynamics of the dopaminergic system as a key component to the understanding of depression. Prog Brain Res. 2008; 172:265-86. DOI: 10.1016/S0079-6123(08)00913-8. View

14.

Sawchenko P, Imaki T, Potter E, Kovacs K, Imaki J, Vale W . The functional neuroanatomy of corticotropin-releasing factor. Ciba Found Symp. 1993; 172:5-21; discussion 21-9. DOI: 10.1002/9780470514368.ch2. View

15.

Ju G, Swanson L, Simerly R . Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat: II. Chemoarchitecture. J Comp Neurol. 1989; 280(4):603-21. DOI: 10.1002/cne.902800410. View

16.

Sawchenko P, Swanson L . The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J Comp Neurol. 1983; 218(2):121-44. DOI: 10.1002/cne.902180202. View

17.

Mantsch J, Baker D, Funk D, Le A, Shaham Y . Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress. Neuropsychopharmacology. 2015; 41(1):335-56. PMC: 4677117. DOI: 10.1038/npp.2015.142. View

18.

Tagliaferro P, Morales M . Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. J Comp Neurol. 2007; 506(4):616-26. PMC: 2440343. DOI: 10.1002/cne.21576. View

19.

Weinstein J, Chohan M, Slifstein M, Kegeles L, Moore H, Abi-Dargham A . Pathway-Specific Dopamine Abnormalities in Schizophrenia. Biol Psychiatry. 2016; 81(1):31-42. PMC: 5177794. DOI: 10.1016/j.biopsych.2016.03.2104. View

20.

Valentino R, Van Bockstaele E . Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur J Pharmacol. 2008; 583(2-3):194-203. PMC: 2349983. DOI: 10.1016/j.ejphar.2007.11.062. View