The Function of Bone Morphogenetic Proteins in the Human Ovary

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2018 Apr 28

PMID 29699076

Citations 9

Authors

Osamu Yoshino

Jia Shi

Yutaka Osuga

Miyuki Harada

Osamu Nishii

Tetsu Yano

Yuji Taketani

Affiliations

Soon will be listed here.

Abstract

The gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH), are of particular importance in ovarian physiology. However, FSH receptors and LH receptors are not expressed until the secondary follicle stage, indicating that initiation of follicular growth is independent of the gonadotropins. Among many intra-ovarian growth factors, many studies have shown that bone morphogenetic proteins (BMPs) play pivotal roles in regulating the early phases of follicular growth. The BMP system induces the gonadotropin system by modulating gonadotropin receptors in early-stage follicles. Interestingly, the BMP system also prevents precocious maturation of the follicle by suppressing luteinization. Signals provoked by the preovulatory LH surge eliminate BMPs, enabling luteinization to progress. Thus, the BMP system and the gonadotropin system seem to cooperate in regulating follicular development, maturation, and luteinization.

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