Pre-operative Use of Dexamethasone Does Not Reduce Incidence or Intensity of Bleaching-induced Tooth Sensitivity. A Triple-blind, Parallel-design, Randomized Clinical Trial

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2018 Apr 27

PMID 29696420

Citations 9

Authors

Luiz Augusto da Costa Poubel

Cresus Vinicius Deppes de Gouvea

Fernanda Signorelli Calazans

Etyene Castro Dip

Wesley Veltri Alves

Stella Soares Marins

Roberta Barcelos

Marcos Oliveira Barceleiro

Affiliations

Soon will be listed here.

Abstract

Objectives: This study evaluated the effect of the administration of pre-operative dexamethasone on tooth sensitivity stemming from in-office bleaching.

Materials And Methods: A triple-blind, parallel-design, randomized clinical trial was conducted on 70 volunteers who received dexamethasone or placebo capsules. The drugs were administered in a protocol of three daily 8-mg doses of the drug, starting 48 h before the in-office bleaching treatment. Two bleaching sessions with 37.5% hydrogen peroxide gel were performed with a 1-week interval. Tooth sensitivity (TS) was recorded on visual analog scales (VAS) and numeric rating scales (NRS) in different periods up to 48 h after bleaching. The color evaluations were also performed. The absolute risk of TS and its intensity were evaluated by using Fisher's exact test. Comparisons of the TS intensity (NRS and VAS data) were performed by using the Mann-Whitney U test and a two-way repeated measures ANOVA and Tukey's test, respectively.

Results: In both groups, a high risk of TS (Dexa 80% x Placebo 94%) was detected. No significant difference was observed in terms of TS intensity. A whitening of approximately 3 shade guide units of the VITA Classical was detected in both groups, which were statistically similar.

Conclusions: It was concluded that the administration pre-operatively of dexamethasone, in the proposed protocol, does not reduce the incidence or intensity of bleaching-induced tooth sensitivity.

Clinical Relevance: The use of dexamethasone drug before in-office bleaching treatment does not reduce incidence or intensity of tooth sensitivity.

Clinical Trial Registration Number: NCT02956070.

Citing Articles

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Effect of preoperative systemic capsaicin on tooth sensitivity after in-office bleaching: A pilot study.

Samimi P, Kachuie M, Jafarian A, Shahtouri M, Khoroushi M Dent Res J (Isfahan). 2024; 21:36.

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Assessment of the effect of experimental gel of pregabalin associated with 35% hydrogen peroxide bleaching on bovine dental enamel: an in vitro study.

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Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching-a double-blind, randomized controlled trial.

Vochikovski L, Favoreto M, Rezende M, Terra R, da Silva K, Farago P Clin Oral Investig. 2022; 27(4):1567-1576.

PMID: 36418502 PMC: 9685084. DOI: 10.1007/s00784-022-04778-2.

Post-Operative Sensitivity and Color Change Due to In-Office Bleaching With the Prior Use of Different Desensitizing Agents: A Systematic Review.

Krishnakumar K, Tandale A, Mehta V, Khade S, Talreja T, Aidasani G Cureus. 2022; 14(4):e24028.

PMID: 35547454 PMC: 9090214. DOI: 10.7759/cureus.24028.

References

Leonard Jr R, Bentley C, Eagle J, Garland G, Knight M, Phillips C . Nightguard vital bleaching: a long-term study on efficacy, shade retention. side effects, and patients' perceptions. J Esthet Restor Dent. 2002; 13(6):357-69. DOI: 10.1111/j.1708-8240.2001.tb01021.x. View

Dahl J, Pallesen U . Tooth bleaching--a critical review of the biological aspects. Crit Rev Oral Biol Med. 2003; 14(4):292-304. DOI: 10.1177/154411130301400406. View

Bjornson C, Klassen T, Williamson J, Brant R, Mitton C, Plint A . A randomized trial of a single dose of oral dexamethasone for mild croup. N Engl J Med. 2004; 351(13):1306-13. DOI: 10.1056/NEJMoa033534. View

Giniger M, Macdonald J, Ziemba S, Felix H . The clinical performance of professionally dispensed bleaching gel with added amorphous calcium phosphate. J Am Dent Assoc. 2005; 136(3):383-92. DOI: 10.14219/jada.archive.2005.0181. View

Rhen T, Cidlowski J . Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. N Engl J Med. 2005; 353(16):1711-23. DOI: 10.1056/NEJMra050541. View

Paravina R, Johnston W, Powers J . New shade guide for evaluation of tooth whitening--colorimetric study. J Esthet Restor Dent. 2007; 19(5):276-83. DOI: 10.1111/j.1708-8240.2007.00118_1.x. View

Hewlett E . Etiology and management of whitening-induced tooth hypersensitivity. J Calif Dent Assoc. 2007; 35(7):499-506. View

Laureano Filho J, Maurette P, Allais M, Cotinho M, Fernandes C . Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal. 2008; 13(2):E129-32. View

Paravina R . New shade guide for tooth whitening monitoring: visual assessment. J Prosthet Dent. 2008; 99(3):178-84. DOI: 10.1016/S0022-3913(08)60041-4. View

10.

Marson F, Sensi L, Vieira L, Araujo E . Clinical evaluation of in-office dental bleaching treatments with and without the use of light-activation sources. Oper Dent. 2008; 33(1):15-22. DOI: 10.2341/07-57. View

11.

Brone B, Peeters P, Marrannes R, Mercken M, Nuydens R, Meert T . Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008; 231(2):150-6. DOI: 10.1016/j.taap.2008.04.005. View

12.

Caviedes-Bucheli J, Ariza-Garcia G, Restrepo-Mendez S, Rios-Osorio N, Lombana N, Munoz H . The effect of tooth bleaching on substance P expression in human dental pulp. J Endod. 2008; 34(12):1462-5. DOI: 10.1016/j.joen.2008.09.013. View

13.

Charakorn P, Cabanilla L, Wagner W, Foong W, Shaheen J, Pregitzer R . The effect of preoperative ibuprofen on tooth sensitivity caused by in-office bleaching. Oper Dent. 2009; 34(2):131-5. DOI: 10.2341/08-33. View

14.

Gurgan S, Cakir F, Yazici E . Different light-activated in-office bleaching systems: a clinical evaluation. Lasers Med Sci. 2009; 25(6):817-22. DOI: 10.1007/s10103-009-0688-x. View

15.

Tay L, Kose C, Loguercio A, Reis A . Assessing the effect of a desensitizing agent used before in-office tooth bleaching. J Am Dent Assoc. 2009; 140(10):1245-51. DOI: 10.14219/jada.archive.2009.0047. View

16.

Markowitz K . Pretty painful: why does tooth bleaching hurt?. Med Hypotheses. 2010; 74(5):835-40. DOI: 10.1016/j.mehy.2009.11.044. View

17.

Alomari Q, El Daraa E . A randomized clinical trial of in-office dental bleaching with or without light activation. J Contemp Dent Pract. 2010; 11(1):E017-24. View

18.

Bernardon J, Sartori N, Ballarin A, Perdigao J, Lopes G, Baratieri L . Clinical performance of vital bleaching techniques. Oper Dent. 2010; 35(1):3-10. DOI: 10.2341/09-008CR. View

19.

de Souza Costa C, Riehl H, Kina J, Sacono N, Hebling J . Human pulp responses to in-office tooth bleaching. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(4):e59-64. DOI: 10.1016/j.tripleo.2009.12.002. View

20.

Samorodnitzky-Naveh G, Grossman Y, Bachner Y, Levin L . Patients' self-perception of tooth shade in relation to professionally objective evaluation. Quintessence Int. 2010; 41(5):e80-3. View